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Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development

Authors
 Kyoung-Won Cho  ;  Sung-Won Cho  ;  Jong-Min Lee  ;  Min-Jung Lee  ;  Hee-Seok Gang  ;  Han-Sung Jung 
Citation
 GENE EXPRESSION PATTERNS, Vol.8(4) : 284-290, 2008 
Journal Title
 GENE EXPRESSION PATTERNS 
ISSN
 1567-133X 
Issue Date
2008
MeSH
Animals ; Extracellular Signal-Regulated MAP Kinases/metabolism* ; Immunohistochemistry ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism* ; Mouth/embryology* ; Mouth/enzymology ; PTEN Phosphohydrolase/metabolism* ; Palate/embryology ; Palate/enzymology ; Phosphatidylinositol 3-Kinases/metabolism* ; Phosphorylation ; Tongue/embryology ; Tongue/enzymology ; Tooth/embryology ; Tooth/enzymology
Keywords
Animals ; Extracellular Signal-Regulated MAP Kinases/metabolism* ; Immunohistochemistry ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism* ; Mouth/embryology* ; Mouth/enzymology ; PTEN Phosphohydrolase/metabolism* ; Palate/embryology ; Palate/enzymology ; Phosphatidylinositol 3-Kinases/metabolism* ; Phosphorylation ; Tongue/embryology ; Tongue/enzymology ; Tooth/embryology ; Tooth/enzymology
Abstract
Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue
Full Text
http://www.sciencedirect.com/science/article/pii/S1567133X07001494
DOI
10.1016/j.gep.2007.12.001
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Jung(이민정)
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Kyoung Won(조경원)
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108132
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