2 198

Cited 0 times in

Implications for tooth development on ENU-induced ectodermal dysplasia mice.

Authors
 Yeun-Jung Kim  ;  Jae-Young Kim  ;  Jae-Woo Cho  ;  Dal-Sun Cha  ;  Min-Jung Lee  ;  Tadokoro Osamu  ;  Hyuk-Jae Kwon  ;  Kyu-Hyuk Cho  ;  Joon H. Lee  ;  Chang-Woo Song  ;  Han-Sung Jung 
Citation
 BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY , Vol.83(2) : 97-103, 2008 
Journal Title
 BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY 
ISSN
 1542-9733 
Issue Date
2008
MeSH
Animals ; Animals, Newborn ; Chromosome Mapping ; Chromosomes, Mammalian ; Ectodermal Dysplasia/chemically induced* ; Ectodermal Dysplasia/embryology ; Ectodermal Dysplasia/genetics ; Ectodysplasins/genetics ; Ectodysplasins/metabolism ; Ethylnitrosourea/toxicity* ; Female ; Gene Expression Regulation, Developmental/drug effects ; Inhibin-beta Subunits/genetics ; Intercellular Signaling Peptides and Proteins/genetics ; Lymphoid Enhancer-Binding Factor 1/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Organogenesis/drug effects ; Signal Transduction/genetics ; Tooth Abnormalities/chemically induced* ; Tooth Abnormalities/embryology ; Tooth Abnormalities/genetics ; Transcription Factor RelA/genetics
Keywords
Animals ; Animals, Newborn ; Chromosome Mapping ; Chromosomes, Mammalian ; Ectodermal Dysplasia/chemically induced* ; Ectodermal Dysplasia/embryology ; Ectodermal Dysplasia/genetics ; Ectodysplasins/genetics ; Ectodysplasins/metabolism ; Ethylnitrosourea/toxicity* ; Female ; Gene Expression Regulation, Developmental/drug effects ; Inhibin-beta Subunits/genetics ; Intercellular Signaling Peptides and Proteins/genetics ; Lymphoid Enhancer-Binding Factor 1/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Organogenesis/drug effects ; Signal Transduction/genetics ; Tooth Abnormalities/chemically induced* ; Tooth Abnormalities/embryology ; Tooth Abnormalities/genetics ; Transcription Factor RelA/genetics
Abstract
BACKGROUND: In this study, the mutated phenotypes were produced by treatment of chemical mutagen, N-ethyl-N-nitrosourea (ENU). We analyzed the mutated mice showing the specific phenotype of ectodermal dysplasia (ED) and examined the affected gene. METHODS: Phenotypes, including size, bone formation, and craniofacial morphology of ENU-induced ED mice, were focused. Tooth development and expression of several molecules were analyzed by histologic observations and immunohistochemistry. We carried out genome-wide screening and quantitative real-time PCR to define the affected and related genes. RESULTS: As examined previously in human ectodermal dysplasia, ENU-induced ED mice showed the specific morphologic deformities in tooth, hair, and craniofacial growth. Tooth development in the ENU-induced ED mice ceased at early cap stage. In addition, skeletal staining showed retardation in craniofacial development. Finally, the affected gene, which would be involved in the mechanism of ED, was located between the marker D3Mit14 and D3Mit319 on chromosome 3. CONCLUSIONS: The affected gene in ENU-induced ED mice showed several defects in ectodermal organogenesis and these results indicate that this gene plays an important role in mouse embryogenesis.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/bdrb.20146/abstract
DOI
10.1002/bdrb.20146
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Jung(이민정)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108131
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse