Cited 1 times in
Implications for tooth development on ENU-induced ectodermal dysplasia mice.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이민정 | - |
dc.contributor.author | 정한성 | - |
dc.date.accessioned | 2015-05-19T17:25:47Z | - |
dc.date.available | 2015-05-19T17:25:47Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1542-9733 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108131 | - |
dc.description.abstract | BACKGROUND: In this study, the mutated phenotypes were produced by treatment of chemical mutagen, N-ethyl-N-nitrosourea (ENU). We analyzed the mutated mice showing the specific phenotype of ectodermal dysplasia (ED) and examined the affected gene. METHODS: Phenotypes, including size, bone formation, and craniofacial morphology of ENU-induced ED mice, were focused. Tooth development and expression of several molecules were analyzed by histologic observations and immunohistochemistry. We carried out genome-wide screening and quantitative real-time PCR to define the affected and related genes. RESULTS: As examined previously in human ectodermal dysplasia, ENU-induced ED mice showed the specific morphologic deformities in tooth, hair, and craniofacial growth. Tooth development in the ENU-induced ED mice ceased at early cap stage. In addition, skeletal staining showed retardation in craniofacial development. Finally, the affected gene, which would be involved in the mechanism of ED, was located between the marker D3Mit14 and D3Mit319 on chromosome 3. CONCLUSIONS: The affected gene in ENU-induced ED mice showed several defects in ectodermal organogenesis and these results indicate that this gene plays an important role in mouse embryogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 97~103 | - |
dc.relation.isPartOf | BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Animals, Newborn | - |
dc.subject.MESH | Chromosome Mapping | - |
dc.subject.MESH | Chromosomes, Mammalian | - |
dc.subject.MESH | Ectodermal Dysplasia/chemically induced* | - |
dc.subject.MESH | Ectodermal Dysplasia/embryology | - |
dc.subject.MESH | Ectodermal Dysplasia/genetics | - |
dc.subject.MESH | Ectodysplasins/genetics | - |
dc.subject.MESH | Ectodysplasins/metabolism | - |
dc.subject.MESH | Ethylnitrosourea/toxicity* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Developmental/drug effects | - |
dc.subject.MESH | Inhibin-beta Subunits/genetics | - |
dc.subject.MESH | Intercellular Signaling Peptides and Proteins/genetics | - |
dc.subject.MESH | Lymphoid Enhancer-Binding Factor 1/genetics | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Organogenesis/drug effects | - |
dc.subject.MESH | Signal Transduction/genetics | - |
dc.subject.MESH | Tooth Abnormalities/chemically induced* | - |
dc.subject.MESH | Tooth Abnormalities/embryology | - |
dc.subject.MESH | Tooth Abnormalities/genetics | - |
dc.subject.MESH | Transcription Factor RelA/genetics | - |
dc.title | Implications for tooth development on ENU-induced ectodermal dysplasia mice. | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Yeun-Jung Kim | - |
dc.contributor.googleauthor | Jae-Young Kim | - |
dc.contributor.googleauthor | Jae-Woo Cho | - |
dc.contributor.googleauthor | Dal-Sun Cha | - |
dc.contributor.googleauthor | Min-Jung Lee | - |
dc.contributor.googleauthor | Tadokoro Osamu | - |
dc.contributor.googleauthor | Hyuk-Jae Kwon | - |
dc.contributor.googleauthor | Kyu-Hyuk Cho | - |
dc.contributor.googleauthor | Joon H. Lee | - |
dc.contributor.googleauthor | Chang-Woo Song | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.identifier.doi | 10.1002/bdrb.20146 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A02785 | - |
dc.relation.journalcode | J00338 | - |
dc.identifier.eissn | 1542-9741 | - |
dc.identifier.pmid | 18357618 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/bdrb.20146/abstract | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Animals, Newborn | - |
dc.subject.keyword | Chromosome Mapping | - |
dc.subject.keyword | Chromosomes, Mammalian | - |
dc.subject.keyword | Ectodermal Dysplasia/chemically induced* | - |
dc.subject.keyword | Ectodermal Dysplasia/embryology | - |
dc.subject.keyword | Ectodermal Dysplasia/genetics | - |
dc.subject.keyword | Ectodysplasins/genetics | - |
dc.subject.keyword | Ectodysplasins/metabolism | - |
dc.subject.keyword | Ethylnitrosourea/toxicity* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Gene Expression Regulation, Developmental/drug effects | - |
dc.subject.keyword | Inhibin-beta Subunits/genetics | - |
dc.subject.keyword | Intercellular Signaling Peptides and Proteins/genetics | - |
dc.subject.keyword | Lymphoid Enhancer-Binding Factor 1/genetics | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred BALB C | - |
dc.subject.keyword | Mice, Inbred C57BL | - |
dc.subject.keyword | Organogenesis/drug effects | - |
dc.subject.keyword | Signal Transduction/genetics | - |
dc.subject.keyword | Tooth Abnormalities/chemically induced* | - |
dc.subject.keyword | Tooth Abnormalities/embryology | - |
dc.subject.keyword | Tooth Abnormalities/genetics | - |
dc.subject.keyword | Transcription Factor RelA/genetics | - |
dc.contributor.alternativeName | Lee, Min Jung | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Lee, Min Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 83 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 97 | - |
dc.citation.endPage | 103 | - |
dc.identifier.bibliographicCitation | BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY , Vol.83(2) : 97-103, 2008 | - |
dc.identifier.rimsid | 35204 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.