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Novel hyaluronic acid (HA) coated drug carriers (HCDCs) for human breast cancer treatment

Authors
 Woochan Hyung  ;  Hyunjoo Ko  ;  Joseph Park  ;  Eunkyung Lim  ;  Sung Bae Park  ;  Young-Joon Park  ;  Ho Geun Yoon  ;  Jin Suck Suh  ;  Seungjoo Haam  ;  Yong-Min Huh 
Citation
 BIOTECHNOLOGY AND BIOENGINEERING, Vol.99(2) : 442-454, 2008 
Journal Title
 BIOTECHNOLOGY AND BIOENGINEERING 
ISSN
 0006-3592 
Issue Date
2008
MeSH
Antibiotics, Antineoplastic/administration & dosage* ; Antibiotics, Antineoplastic/chemistry ; Breast Neoplasms/drug therapy* ; Cell Line, Tumor/drug effects ; Chemistry, Pharmaceutical ; Doxorubicin/administration & dosage* ; Doxorubicin/chemistry ; Drug Carriers/chemistry* ; Female ; Humans ; Hyaluronic Acid/chemistry* ; Nanoparticles/chemistry* ; Tissue Engineering
Keywords
Antibiotics, Antineoplastic/administration & dosage* ; Antibiotics, Antineoplastic/chemistry ; Breast Neoplasms/drug therapy* ; Cell Line, Tumor/drug effects ; Chemistry, Pharmaceutical ; Doxorubicin/administration & dosage* ; Doxorubicin/chemistry ; Drug Carriers/chemistry* ; Female ; Humans ; Hyaluronic Acid/chemistry* ; Nanoparticles/chemistry* ; Tissue Engineering
Abstract
Hyaluronic acid (HA) coated drug carriers (HCDCs) were successfully synthesized by chemical conjugation method for targeted delivery of doxorubicin (DOX) as a prototype anticancer drug to CD44 expressed human breast cancer cell. From XPS analysis, the HCDCs by conjugation methods demonstrated the superior HA fixation amount and colloidal stability compared with the nanoparticles by nanoprecipitation. The cytotoxicity of the HCDCs formulation accessed by the MTT assay against the higher CD44 expressed cell line (MDA-MB-231) and lower CD44 expressed cell line (ZR-75-1) human breast cancer cell lines demonstrated that the HCDCs formulation exhibited excellent tumoricidal effect and their affinity to cancer cells was predominant. The in vitro drug release profile of the HCDCs showed sustained release behavior and after 14 days, 80% of the encapsulated DOX was released due to a high release rate of DOX from HCDCs. We synthesized that HCDCs have therapeutic potentials of cancer as a target specific fashion by increasing the tumoricidal efficacy of targeted cancer cells while reducing their cytotoxicity of non-targeted cells to minimize the side effect
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/bit.21578/abstract
DOI
10.1002/bit.21578
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
Hyung, Woo Chan(형우찬)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108109
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