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자발 운동 및 부유 환경 조성에 의한 선조체 내 신경세포 생성 유도

Other Titles
 Induction of Striatal Neurogenesis by Voluntary Exercise and Environmental Enrichment 
 민경훈  ;  임상희  ;  배병우  ;  김은상  ;  박은숙  ;  박창일  ;  조성래 
 Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지), Vol.32(6) : 632-636, 2008 
Journal Title
Journal of the Korean Academy of Rehabilitation Medicine(대한재활의학회지)
Issue Date
Voluntary exercise ; Environmental enrichment ; Neurogenesis ; Subventricular zone ; Striatum
Objective: To investigate that neurogenesis in the subventricular zone (SVZ), which is already known as neurogenic area where neural stem/progenitor cells persist, and the striatum, which is non-neurogenic area, might be induced by voluntary exercise (VEx) or environmental enrichment (EE), and compare the extent of the neurogenesis with untreated controls.
Method: Total 12 C57BL/6 mice, 2∼3 months old, were recruited as follows; voluntary wheel runner, EE and control. For 2 weeks, VEx group was housed in rat cage (48×26 cm) with 2 running wheels with 3∼4 animals/cage, and EE group was housed in the living condition of huge cage (86×76 cm), social interaction (13∼14 mice/cage) and objects such as toys, tunnels and running wheel, whereas control group was placed in the standard cage (30×18 cm).
Results: VEx and EE tended to increase the densities of mitotic marker BrdU+ cells in SVZ and striatum. They also exhibited more BrdU+ cells (/mm3) into the striatum, even though they did not show statistical significance. Moreover, EE group showed significant increment of the newly generated neurons coexpressed with BrdU+ and ՂIII-tubulin+ (/mm3) in SVZ and striatum as compared to those of controls.
Conclusion: Voluntary physical exercise and EE induced cell proliferation and neurogenesis in both SVZ and striatum. Characteristically, EE could significantly induce neurogenesis in striatum, non-neurogenic area as well as SVZ, typical neurogenic area. Therefore, this strategy might be used to activate neural regeneration in various central nervous system diseases
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1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun Sook(박은숙) ORCID logo https://orcid.org/0000-0002-9144-3063
Park, Chang Il(박창일)
Cho, Sung-Rae(조성래) ORCID logo https://orcid.org/0000-0003-1429-2684
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