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자발 운동 및 부유 환경 조성에 의한 선조체 내 신경세포 생성 유도
DC Field | Value | Language |
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dc.contributor.author | 박은숙 | - |
dc.contributor.author | 박창일 | - |
dc.contributor.author | 조성래 | - |
dc.date.accessioned | 2015-05-19T17:21:36Z | - |
dc.date.available | 2015-05-19T17:21:36Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1225-584X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107998 | - |
dc.description.abstract | Objective: To investigate that neurogenesis in the subventricular zone (SVZ), which is already known as neurogenic area where neural stem/progenitor cells persist, and the striatum, which is non-neurogenic area, might be induced by voluntary exercise (VEx) or environmental enrichment (EE), and compare the extent of the neurogenesis with untreated controls. Method: Total 12 C57BL/6 mice, 2∼3 months old, were recruited as follows; voluntary wheel runner, EE and control. For 2 weeks, VEx group was housed in rat cage (48×26 cm) with 2 running wheels with 3∼4 animals/cage, and EE group was housed in the living condition of huge cage (86×76 cm), social interaction (13∼14 mice/cage) and objects such as toys, tunnels and running wheel, whereas control group was placed in the standard cage (30×18 cm). Results: VEx and EE tended to increase the densities of mitotic marker BrdU+ cells in SVZ and striatum. They also exhibited more BrdU+ cells (/mm3) into the striatum, even though they did not show statistical significance. Moreover, EE group showed significant increment of the newly generated neurons coexpressed with BrdU+ and ՂIII-tubulin+ (/mm3) in SVZ and striatum as compared to those of controls. Conclusion: Voluntary physical exercise and EE induced cell proliferation and neurogenesis in both SVZ and striatum. Characteristically, EE could significantly induce neurogenesis in striatum, non-neurogenic area as well as SVZ, typical neurogenic area. Therefore, this strategy might be used to activate neural regeneration in various central nervous system diseases | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 632~636 | - |
dc.relation.isPartOf | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 자발 운동 및 부유 환경 조성에 의한 선조체 내 신경세포 생성 유도 | - |
dc.title.alternative | Induction of Striatal Neurogenesis by Voluntary Exercise and Environmental Enrichment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학) | - |
dc.contributor.googleauthor | 민경훈 | - |
dc.contributor.googleauthor | 임상희 | - |
dc.contributor.googleauthor | 배병우 | - |
dc.contributor.googleauthor | 김은상 | - |
dc.contributor.googleauthor | 박은숙 | - |
dc.contributor.googleauthor | 박창일 | - |
dc.contributor.googleauthor | 조성래 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01611 | - |
dc.contributor.localId | A01717 | - |
dc.contributor.localId | A03831 | - |
dc.relation.journalcode | J01803 | - |
dc.identifier.pmid | Voluntary exercise ; Environmental enrichment ; Neurogenesis ; Subventricular zone ; Striatum | - |
dc.subject.keyword | Voluntary exercise | - |
dc.subject.keyword | Environmental enrichment | - |
dc.subject.keyword | Neurogenesis | - |
dc.subject.keyword | Subventricular zone | - |
dc.subject.keyword | Striatum | - |
dc.contributor.alternativeName | Park, Eun Sook | - |
dc.contributor.alternativeName | Park, Chang Il | - |
dc.contributor.alternativeName | Cho, Sung Rae | - |
dc.contributor.affiliatedAuthor | Park, Eun Sook | - |
dc.contributor.affiliatedAuthor | Park, Chang Il | - |
dc.contributor.affiliatedAuthor | Cho, Sung Rae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 32 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 632 | - |
dc.citation.endPage | 636 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지), Vol.32(6) : 632-636, 2008 | - |
dc.identifier.rimsid | 50052 | - |
dc.type.rims | ART | - |
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