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The effects of hydroxyapatite/calcium phosphate glass scaffold and its surface modification with bovine serum albumin on 1-wall intrabony defects of beagle dogs: a preliminary study.

Authors
 Yoo-Jung Um  ;  Ui-Won Jung  ;  Gyung-Joon Chae  ;  Chang-Sung Kim  ;  Yong-Keun Lee  ;  Kyoo-Sung Cho  ;  Chong-Kwan Kim  ;  Seong-Ho Choi 
Citation
 BIOMEDICAL MATERIALS, Vol.3(4) : 044113, 2008 
Journal Title
 BIOMEDICAL MATERIALS 
ISSN
 1748-6041 
Issue Date
2008
MeSH
Animals ; Bone Regeneration/drug effects ; Bone Resorption ; Bone Substitutes/chemistry ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Calcium Phosphates/chemistry* ; Cattle ; Dental Cementum/chemistry ; Dogs ; Durapatite/chemistry* ; Glass ; Materials Testing ; Serum Albumin, Bovine/chemistry* ; Surface Properties ; Tissue Engineering/methods
Keywords
Animals ; Bone Regeneration/drug effects ; Bone Resorption ; Bone Substitutes/chemistry ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Calcium Phosphates/chemistry* ; Cattle ; Dental Cementum/chemistry ; Dogs ; Durapatite/chemistry* ; Glass ; Materials Testing ; Serum Albumin, Bovine/chemistry* ; Surface Properties ; Tissue Engineering/methods
Abstract
The purpose of this study was to evaluate the effects of biphasic hydroxyapatite/calcium phosphate glass (HA/CPG) scaffold and its surface modification with bovine serum albumin (BSA) on periodontal regeneration. 1-wall intrabony defects were surgically created on five beagle dogs. HA/CPG scaffolds, with a hydroxyapatite (HA)/calcium phosphate glass (CPG) ratio of 95:5 by weight (%) and surface modification done by 2% bovine serum albumin, were used. The control group received surgical flap operation, and the experimental groups were filled with HA/CPG scaffolds and HA/CPG(BSA) scaffolds. The animals were sacrificed eight weeks after surgery. Histological findings revealed better space maintenance in the experimental groups than the control group, and showed new bone formation intermittently in between the residual material particles. The newly formed bone was mostly woven bone and the residual particles were undergoing resorption. Cementum regeneration was observed with limited root resorption in all the groups. Histometric analysis also revealed greater mean values in new bone formation, cementum regeneration and bone area than the control group in both experimental groups. However, similar findings were presented between HA/CPG and HA/CPG(BSA). The result of the present study revealed the newly fabricated HA/CPG scaffold to have a potential use as a bone substitute material.
Full Text
http://iopscience.iop.org/1748-605X/3/4/044113/
DOI
10.1088/1748-6041/3/4/044113
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Lee, Yong Keun(이용근)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107978
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