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신이식 환자에 있어서 이식 초기의 요산 수치와 사구체 여과율 변화량과의 관계

Other Titles
 The Effect of Uric Acid on GFR in Early Period after Kidney Transplantation 
Authors
 박선영  ;  김동기  ;  장제현  ;  김현욱  ;  김은영  ;  박정탁  ;  장태익  ;  유태현  ;  김범석  ;  강신욱  ;  이호영  ;  한대석  ;  김명수  ;  김순일  ;  최규헌 
Citation
 Korean Journal of Nephrology, Vol.27(6) : 712-719, 2008 
Journal Title
 Korean Journal of Nephrology 
ISSN
 1975-9460 
Issue Date
2008
Abstract
Purpose : Hyperuricemia is a common complication occurring shortly after kidney transplantation. Although increased uric acid level is a risk factor for cardiovascular disease and mortality, the relationship between uric acid level and graft function after transplantation has been a controversial issue. Therefore, we investigated the effects of uric acid on glomerular filtration rate (GFR) and graft survival in the early periods of kidney transplantation. Methods : Data were collected from 245 patients who underwent kidney transplantation between 2002 and 2004 at Yonsei University Medical Center. Uric acid level and estimated GFR were measured monthly during the first 6 months and then yearly for 3 years. Results : The mean age of the study population was 40.2±11.7 years. The proportion of patients with hyperuricemia (uric acid ≥6.8 mg/dL) showed increment during the 3 year follow up. Increased serum uric acid level showed a negative correlation with estimated GFR during the initial 6 months after transplantation (r=-0.026, p<0.05). In Kaplan-Meier analysis, patients with a mean uric acid level higher than 6.8 mg/dL during the first 6 months showed a lower cumulative graft survival during the consecutive 3 years compared to patients with a uric acid level lower than 6.8 mg/dL (HR 1.7, p=0.003). Conclusion : Uric acid levels were associated with the changes of GFR in the initial 6 months of kidney transplantation, and the hyperuricemia during the early stages of transplantation might influence the long term graft survival.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강신욱(Kang, Shin Wook) ORCID logo https://orcid.org/0000-0002-5677-4756
김동기(Kim, Dong Ki)
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김범석(Kim, Beom Seok) ORCID logo https://orcid.org/0000-0002-5732-2583
김순일(Kim, Soon Il) ORCID logo https://orcid.org/0000-0002-0783-7538
김현욱(Kim, Hyun Wook) ORCID logo https://orcid.org/0000-0002-4274-7562
박선영(Park, Sun Young)
박정탁(Park, Jung Tak) ORCID logo https://orcid.org/0000-0002-2325-8982
유태현(Yoo, Tae Hyun) ORCID logo https://orcid.org/0000-0002-9183-4507
이호영(Lee, Ho Yung)
장제현(Chang, Jae Hyun)
장태익(Chang, Tae Ik)
최규헌(Choi, Kyu Hun) ORCID logo https://orcid.org/0000-0003-0095-9011
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107869
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