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Thyroid incidentalomas identified by 18F-FDG PET: sonographic correlation

 Jin Young Kwak  ;  Eun-Kyung Kim  ;  Mijin Yun  ;  Arthur Cho  ;  Min Jung Kim  ;  Eun Ju Son  ;  Ki Keun Oh 
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.191(2) : 598-603, 2008 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle ; Diagnosis, Differential ; Female ; Fluorodeoxyglucose F18 ; Humans ; Incidental Findings ; Logistic Models ; Male ; Middle Aged ; ROC Curve ; Radiopharmaceuticals ; Retrospective Studies ; Thyroid Neoplasms/diagnostic imaging* ; Tomography, Emission-Computed* ; Ultrasonography, Interventional
cancer ; FDG PET ; fine-needle aspiration biopsy ; PET ; sonography ; thyroid incidentalomas
OBJECTIVE: The purpose of this study was to evaluate the risk of malignancy of thyroid incidentalomas detected on (18)F-FDG PET and the diagnostic accuracy of sonography for differentiating benign from malignant focal thyroid incidentalomas that were detected on FDG PET. MATERIALS AND METHODS: Retrospective review was performed of a database of 87 focal thyroid lesions seen on FDG PET and sonography. Forty-two focal lesions were malignant. We compared the accuracy of the maximum standard uptake value (SUV) to differentiate benign from malignant thyroid lesions. We classified the thyroid nodules as probably benign or suspicious for malignancy by the sonographic features. Statistical analyses compared two subgroups by sonographic classifications between benign and malignant thyroid lesions. RESULTS: The maximum SUV of the malignant nodules was not significantly higher than that of benign lesions. Thirty-seven (75.5%) of 49 lesions with suspicious sonographic findings revealed malignancy on cytopathology, compared with five (13.2%) of 38 lesions that showed probably benign sonographic findings. These differences were statistically significant using a kappa test (kappa = 0.675, p = 0.001) and logistic regression (odds ratio = 26.2, p = 0.001). CONCLUSION: The probability (48.3%) of malignancy of focal thyroid incidentalomas seen on FDG PET is high. The maximum SUV of thyroid cancer is not significantly higher than that of benign lesions. The probability (13.2%) of malignancy is much lower when the sonographic findings appear benign, as compared with a significantly higher probability (75.5%) of malignancy when the sonographic findings are suspicious for malignancy
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1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Oh, Ki Keun(오기근)
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
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