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Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis

 Chang Youl Lee  ;  Jeong Hee Jeon  ;  Hyung Jung Kim  ;  Dong Hwan Shin  ;  Tae Woong Roh  ;  Chul Min Ahn  ;  Yoon Soo Chang 
 Korean Journal of Internal Medicine, Vol.23(3) : 116-120, 2008 
Journal Title
 Korean Journal of Internal Medicine 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Animals ; Carcinoma, Non-Small-Cell Lung/immunology* ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Female ; Humans ; Immunohistochemistry ; Insulin-Like Growth Factor I/biosynthesis* ; Male ; Mice ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Receptor, IGF Type 1/biosynthesis*
IGF ; IGF-1R ; Immunohistochemistry ; NSCLC
BACKGROUND/AIMS: The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and its prognostic implications in non-small-cell lung cancer (NSCLC) are still controversial. METHODS: Seventy-one paraffin-embedded tissue sections from stage I NSCLC patients were stained using a mouse monoclonal antibody against human IGF-1R. RESULTS: The intensity and frequency of IGF-1R expression on the membrane and cytoplasm of cancer cells was evaluated and scored using a semiquantitative system. IGF-1R expression was detected in nine of 71 (12.7%) cases. No significant relationship was found between clinical/histopathological parameters and IGF-1R expression. None of the patients whose tumor expressed IGF-1R had experienced distant metastasis or cancer-related death, although the difference did not reach statistical significance. CONCLUSIONS: We conclude that IGF-1R expression may not be a major prognostic factor for stage I NSCLC.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Noh, Tae Woong(노태웅)
Shin, Dong Hwan(신동환)
Ahn, Chul Min(안철민)
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
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