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Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis

DC FieldValueLanguage
dc.contributor.author신동환-
dc.contributor.author장윤수-
dc.contributor.author김형중-
dc.contributor.author노태웅-
dc.contributor.author안철민-
dc.date.accessioned2015-05-19T16:42:10Z-
dc.date.available2015-05-19T16:42:10Z-
dc.date.issued2008-
dc.identifier.issn1226-3303-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106786-
dc.description.abstractBACKGROUND/AIMS: The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and its prognostic implications in non-small-cell lung cancer (NSCLC) are still controversial. METHODS: Seventy-one paraffin-embedded tissue sections from stage I NSCLC patients were stained using a mouse monoclonal antibody against human IGF-1R. RESULTS: The intensity and frequency of IGF-1R expression on the membrane and cytoplasm of cancer cells was evaluated and scored using a semiquantitative system. IGF-1R expression was detected in nine of 71 (12.7%) cases. No significant relationship was found between clinical/histopathological parameters and IGF-1R expression. None of the patients whose tumor expressed IGF-1R had experienced distant metastasis or cancer-related death, although the difference did not reach statistical significance. CONCLUSIONS: We conclude that IGF-1R expression may not be a major prognostic factor for stage I NSCLC.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfKOREAN JOURNAL OF INTERNAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnimals-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/immunology*-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/mortality-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInsulin-Like Growth Factor I/biosynthesis*-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHReceptor, IGF Type 1/biosynthesis*-
dc.titleClinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorChang Youl Lee-
dc.contributor.googleauthorJeong Hee Jeon-
dc.contributor.googleauthorHyung Jung Kim-
dc.contributor.googleauthorDong Hwan Shin-
dc.contributor.googleauthorTae Woong Roh-
dc.contributor.googleauthorChul Min Ahn-
dc.contributor.googleauthorYoon Soo Chang-
dc.identifier.doi10.3904/kjim.2008.23.3.116-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02098-
dc.contributor.localIdA02269-
dc.contributor.localIdA03456-
dc.contributor.localIdA01158-
dc.contributor.localIdA01298-
dc.relation.journalcodeJ02883-
dc.identifier.eissn2005-6648-
dc.identifier.pmid18787363-
dc.subject.keywordIGF-
dc.subject.keywordIGF-1R-
dc.subject.keywordImmunohistochemistry-
dc.subject.keywordNSCLC-
dc.contributor.alternativeNameShin, Dong Hwan-
dc.contributor.alternativeNameAhn, Chul Min-
dc.contributor.alternativeNameChang, Yoon Soo-
dc.contributor.alternativeNameKim, Hyung Jung-
dc.contributor.alternativeNameNoh, Tae Woong-
dc.contributor.affiliatedAuthorShin, Dong Hwan-
dc.contributor.affiliatedAuthorAhn, Chul Min-
dc.contributor.affiliatedAuthorChang, Yoon Soo-
dc.contributor.affiliatedAuthorKim, Hyung Jung-
dc.contributor.affiliatedAuthorNoh, Tae Woong-
dc.rights.accessRightsfree-
dc.citation.volume23-
dc.citation.number3-
dc.citation.startPage116-
dc.citation.endPage120-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF INTERNAL MEDICINE, Vol.23(3) : 116-120, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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