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아급성 육아종성 갑상샘염의 세침흡인 세포소견- 아급성 육아종성 갑상샘염 10예의 임상-세포소견 및 면역세포염색 소견 분석

Other Titles
 Fine Needle Aspiration Cytology of Subacute Granulomatous Thyroiditis: A Clinico-Cytological Review of 10 Cases with Immunocytochemical Analysis. 
Authors
 Do Kyung Kim  ;  Ju-Yeon Pyo  ;  Jongpil Park  ;  Lianhua Jin  ;  Woo Hee Jeong  ;  Eun Ju Son  ;  SoonWon Hong 
Citation
 Korean Journal of Cytopathology (대한세포병리학회지), Vol.19(1) : 27-33, 2008 
Journal Title
 Korean Journal of Cytopathology (대한세포병리학회지) 
ISSN
 1017-0391 
Issue Date
2008
Keywords
Fine needle, Biopsy ; Thyroiditis ; Subacute ; Immuno histochemistry
Abstract
Although subacute granulomatous thyroiditis(SGT) is usually diagnosed clinically, papillary carcinoma or other thyroid conditions must be considered in the differential diagnosis. We retrospectively reviewed the clinical and fine-needle aspiration(FNA) cytologic findings seen in 10 SGT cases to decide what are the most reliable cytologic findings and the most helpful molecular tools for reaching a confident cytologic diagnosis. The most representative smear slides were retrieved to perform immunocytochemistry for cytokeratin19(CK19) and Ret protein. Five papillary carcinomas(PTCs) were included as controls. The constant and typical cytologic findings of SGT were multinucleated giant cells(MGCs) (100%), epithelioid granulomas(90%), an inflammatory dirty background(90%) and plump transformed follicular cells(80%) without fire-flare cells, oncocytic cells or transformed lymphocytes. The immunoreactivities for CK19(37.5%) and Ret(10%) of the follicular cells of SGT were less than those(CK19 and Ret:100%) of PTC. CK19 immunoreactivity of the MGCs was seen in only one case of PTC. There was no significant difference between CK19 and Ret immunocytochemical staining for the MGCs of both SGT and PTC. The results of this study demonstrate that the cytological diagnosis of SGT can be improved by employing a combination of the typical and constant diagnostic cytological features and immunocytochemical results.
Files in This Item:
T200800557.pdf Download
DOI
10.3338/kjc.2008.19.1.27
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Pil(박종필) ORCID logo https://orcid.org/0000-0002-6525-3012
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Jung, Woo Hee(정우희)
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106760
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