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Chemicals that modulate stem cell differentiation

Authors
 Ki-Chul Hwang  ;  Ji Young Kim  ;  Woochul Chang  ;  Dae-Sung Kim  ;  Soyeon Lim  ;  Sang-Moon Kang  ;  Byeong-Wook Song  ;  Hye-Yeong Ha  ;  Yong Joon Huh  ;  In-Geol Choi  ;  Dong-Youn Hwang  ;  Heesang Song  ;  Yangsoo Jang  ;  Namsik Chung  ;  Sung-Hou Kim  ;  Dong-Wook Kim 
Citation
 Proceedings of the National Academy of Sciences of the United States of America, Vol.105(21) : 7467-7471, 2008 
Journal Title
 Proceedings of the National Academy of Sciences of the United States of America 
ISSN
 0027-8424 
Issue Date
2008
MeSH
Animals ; Cell Differentiation/drug effects* ; Chondrocytes/cytology ; Embryonic Stem Cells/drug effects* ; Embryonic Stem Cells/enzymology ; Mesenchymal Stromal Cells/drug effects* ; Mesenchymal Stromal Cells/enzymology ; Mice ; Neurons/cytology ; Protein Kinase Inhibitors/pharmacology* ; Rats
Keywords
chemical modulation ; differentiation agonists ; dopaminergic neurons ; chondrocytes
Abstract
Important cellular processes such as cell fate are likely to be controlled by an elaborate orchestration of multiple signaling pathways, many of which are still not well understood or known. Because protein kinases, the members of a large family of proteins involved in modulating many known signaling pathways, are likely to play important roles in balancing multiple signals to modulate cell fate, we focused our initial search for chemical reagents that regulate stem cell fate among known inhibitors of protein kinases. We have screened 41 characterized inhibitors of six major protein kinase subfamilies to alter the orchestration of multiple signaling pathways involved in differentiation of stem cells. We found that some of them cause recognizable changes in the differentiation rates of two types of stem cells, rat mesenchymal stem cells (MSCs) and mouse embryonic stem cells (ESCs). Among many, we describe the two most effective derivatives of the same scaffold compound, isoquinolinesulfonamide, on the stem cell differentiation: rat MSCs to chondrocytes and mouse ESCs to dopaminergic neurons.
Files in This Item:
T200800404.pdf Download
DOI
10.1073/pnas.0802825105
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kim, Dae Sung(김대성)
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0002-5025-1532
Kim, Ji Young(김지영)
Song, Byeong Wook(송병욱)
Lim, So Yeon(임소연)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chang, Woo Chul(장우철)
Chung, Nam Sik(정남식)
Ha, Hye Yeong(하혜영)
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106572
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