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Chemicals that modulate stem cell differentiation

Authors
 Ki-Chul Hwang  ;  Ji Young Kim  ;  Woochul Chang  ;  Dae-Sung Kim  ;  Soyeon Lim  ;  Sang-Moon Kang  ;  Byeong-Wook Song  ;  Hye-Yeong Ha  ;  Yong Joon Huh  ;  In-Geol Choi  ;  Dong-Youn Hwang  ;  Heesang Song  ;  Yangsoo Jang  ;  Namsik Chung  ;  Sung-Hou Kim  ;  Dong-Wook Kim 
Citation
 Proceedings of the National Academy of Sciences of the United States of America, Vol.105(21) : 7467-7471, 2008 
Journal Title
 Proceedings of the National Academy of Sciences of the United States of America 
ISSN
 0027-8424 
Issue Date
2008
Abstract
Important cellular processes such as cell fate are likely to be controlled by an elaborate orchestration of multiple signaling pathways, many of which are still not well understood or known. Because protein kinases, the members of a large family of proteins involved in modulating many known signaling pathways, are likely to play important roles in balancing multiple signals to modulate cell fate, we focused our initial search for chemical reagents that regulate stem cell fate among known inhibitors of protein kinases. We have screened 41 characterized inhibitors of six major protein kinase subfamilies to alter the orchestration of multiple signaling pathways involved in differentiation of stem cells. We found that some of them cause recognizable changes in the differentiation rates of two types of stem cells, rat mesenchymal stem cells (MSCs) and mouse embryonic stem cells (ESCs). Among many, we describe the two most effective derivatives of the same scaffold compound, isoquinolinesulfonamide, on the stem cell differentiation: rat MSCs to chondrocytes and mouse ESCs to dopaminergic neurons.
Files in This Item:
T200800404.pdf Download
DOI
10.1073/pnas.0802825105
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
Yonsei Authors
김대성(Kim, Dae Sung)
김동욱(Kim, Dong Wook) ORCID logo https://orcid.org/0000-0002-5025-1532
김지영(Kim, Ji Young)
송병욱(Song, Byeong Wook)
임소연(Lim, So Yeon)
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
장우철(Chang, Woo Chul)
정남식(Chung, Nam Sik)
하혜영(Ha, Hye Yeong)
황기철(Hwang, Ki Chul)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106572
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