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Cited 34 times in

Chemicals that modulate stem cell differentiation

DC FieldValueLanguage
dc.contributor.author김대성-
dc.contributor.author김동욱-
dc.contributor.author김지영-
dc.contributor.author송병욱-
dc.contributor.author임소연-
dc.contributor.author장양수-
dc.contributor.author장우철-
dc.contributor.author정남식-
dc.contributor.author하혜영-
dc.contributor.author황기철-
dc.date.accessioned2015-05-19T16:35:02Z-
dc.date.available2015-05-19T16:35:02Z-
dc.date.issued2008-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106572-
dc.description.abstractImportant cellular processes such as cell fate are likely to be controlled by an elaborate orchestration of multiple signaling pathways, many of which are still not well understood or known. Because protein kinases, the members of a large family of proteins involved in modulating many known signaling pathways, are likely to play important roles in balancing multiple signals to modulate cell fate, we focused our initial search for chemical reagents that regulate stem cell fate among known inhibitors of protein kinases. We have screened 41 characterized inhibitors of six major protein kinase subfamilies to alter the orchestration of multiple signaling pathways involved in differentiation of stem cells. We found that some of them cause recognizable changes in the differentiation rates of two types of stem cells, rat mesenchymal stem cells (MSCs) and mouse embryonic stem cells (ESCs). Among many, we describe the two most effective derivatives of the same scaffold compound, isoquinolinesulfonamide, on the stem cell differentiation: rat MSCs to chondrocytes and mouse ESCs to dopaminergic neurons.-
dc.description.statementOfResponsibilityopen-
dc.format.extent7467~7471-
dc.relation.isPartOfPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Differentiation/drug effects*-
dc.subject.MESHChondrocytes/cytology-
dc.subject.MESHEmbryonic Stem Cells/drug effects*-
dc.subject.MESHEmbryonic Stem Cells/enzymology-
dc.subject.MESHMesenchymal Stromal Cells/drug effects*-
dc.subject.MESHMesenchymal Stromal Cells/enzymology-
dc.subject.MESHMice-
dc.subject.MESHNeurons/cytology-
dc.subject.MESHProtein Kinase Inhibitors/pharmacology*-
dc.subject.MESHRats-
dc.titleChemicals that modulate stem cell differentiation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorKi-Chul Hwang-
dc.contributor.googleauthorJi Young Kim-
dc.contributor.googleauthorWoochul Chang-
dc.contributor.googleauthorDae-Sung Kim-
dc.contributor.googleauthorSoyeon Lim-
dc.contributor.googleauthorSang-Moon Kang-
dc.contributor.googleauthorByeong-Wook Song-
dc.contributor.googleauthorHye-Yeong Ha-
dc.contributor.googleauthorYong Joon Huh-
dc.contributor.googleauthorIn-Geol Choi-
dc.contributor.googleauthorDong-Youn Hwang-
dc.contributor.googleauthorHeesang Song-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorNamsik Chung-
dc.contributor.googleauthorSung-Hou Kim-
dc.contributor.googleauthorDong-Wook Kim-
dc.identifier.doi10.1073/pnas.0802825105-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00367-
dc.contributor.localIdA02026-
dc.contributor.localIdA03448-
dc.contributor.localIdA03452-
dc.contributor.localIdA03585-
dc.contributor.localIdA04263-
dc.contributor.localIdA04456-
dc.contributor.localIdA00981-
dc.contributor.localIdA00406-
dc.contributor.localIdA03373-1-
dc.relation.journalcodeJ02550-
dc.identifier.eissn1091-6490-
dc.identifier.pmid18480249-
dc.subject.keywordchemical modulation-
dc.subject.keyworddifferentiation agonists-
dc.subject.keyworddopaminergic neurons-
dc.subject.keywordchondrocytes-
dc.contributor.alternativeNameKim, Dae Sung-
dc.contributor.alternativeNameKim, Dong Wook-
dc.contributor.alternativeNameKim, Ji Young-
dc.contributor.alternativeNameSong, Byeong Wook-
dc.contributor.alternativeNameLim, So Yeon-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChang, Woo Chul-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameHa, Hye Yeong-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.contributor.affiliatedAuthorKim, Dae Sung-
dc.contributor.affiliatedAuthorSong, Byeong Wook-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChang, Woo Chul-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorHa, Hye Yeong-
dc.contributor.affiliatedAuthorHwang, Ki Chul-
dc.contributor.affiliatedAuthorKim, Ji Young-
dc.contributor.affiliatedAuthorKim, Dong Wook-
dc.contributor.affiliatedAuthorLim, So Yeon-
dc.rights.accessRightsfree-
dc.citation.volume105-
dc.citation.number21-
dc.citation.startPage7467-
dc.citation.endPage7471-
dc.identifier.bibliographicCitationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.105(21) : 7467-7471, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers

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