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Prefrontal functional dissociation in the semantic network of patients with schizophrenia

Authors
 Il Ho Park  ;  Hae-Jeong Park  ;  Ji-Won Chun  ;  EungYeop Kim  ;  Jae-Jin Kim 
Citation
 NEUROREPORT, Vol.19(14) : 1391-1395, 2008 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
2008
MeSH
Adult ; Dissociative Disorders/physiopathology* ; Female ; Frontal Lobe/physiopathology ; Functional Laterality/physiology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests ; Prefrontal Cortex/physiopathology* ; Reaction Time/physiology ; Schizophrenia/physiopathology* ; Semantics* ; Temporal Lobe/physiopathology ; Verbal Behavior/physiology
Keywords
functional MRI ; inferior frontal gyrus ; inferior frontal sulcus ; semantic network ; superior temporal sulcus ; thought disorder
Abstract
We examined whether deficient prefrontal control over the semantic network exists in patients with schizophrenia. Fourteen patients with schizophrenia and 14 healthy controls performed a comparison task, judging semantic congruity according to an abstract category in an event-related functional MRI paradigm. In the control group, prefrontal-temporal networks consisting of the left inferior frontal gyrus and right inferior frontal sulcus converging at the left posterior superior temporal sulcus were identified as activated during semantic demand of incongruence. In the patients with schizophrenia, we observed a loss of the recruitment of the right inferior frontal sulcus and the prefrontal-temporal network. These findings indicate that cognitive modulation of semantic processing may be dysfunctional in patients with schizophrenia.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200809170-00009&LSLINK=80&D=ovft
DOI
10.1097/WNR.0b013e32830cebff
Appears in Collections:
5. Research Institutes (연구소) > Institute of Behavioral Sciences in Medicine (의학행동과학연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Yeop(김응엽)
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Il Ho(박일호)
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106439
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