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Dysfunctional modulation of emotional interference in the medial prefrontal cortex in patients with schizophrenia

 Il Ho Park  ;  Hae-Jeong Park  ;  Ji-Won Chun  ;  Eung Yeop Kim  ;  Jae-Jin Kim 
 NEUROSCIENCE LETTERS, Vol.440(2) : 119-124, 2008 
Journal Title
Issue Date
Cognition/physiology ; Emotions/physiology* ; Female ; Gyrus Cinguli/pathology ; Gyrus Cinguli/physiopathology ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Male ; Mental Processes/physiology ; Neuropsychological Tests/statistics & numerical data ; Prefrontal Cortex/pathology ; Prefrontal Cortex/physiopathology* ; Reaction Time/physiology ; Schizophrenia/pathology ; Schizophrenia/physiopathology* ; Task Performance and Analysis
Anterior cingulate ; Emotional Stroop ; FMRI ; Schizophrenia ; Subgenual cingulate gyrus
Patients with schizophrenia have impairment in cognitive-emotional interaction that is reflected in delusion formation and poor social functioning. Although monitoring deficits in the anterior cingulate have been observed in schizophrenia, the involvement of the affective division of the anterior cingulate implicated in cognitive modulation of emotional processing has not been directly addressed in schizophrenia. In this study, we examined the function of the affective division of the anterior cingulate and the related neural systems by using a modified emotional Stroop fMRI paradigm. Fourteen patients with schizophrenia and fourteen healthy controls performed an emotional appraisal task with semantically relevant emotional interferences during fMRI scanning. The patients with schizophrenia were significantly less efficient than the healthy controls during the emotional incongruence trials. When emotionally incongruent trials were compared to congruent trials, relative deactivations of the subgenual cingulate gyrus and the ventromedial prefrontal cortex observed in the healthy controls were not found in the patient group and activities of these regions inversely correlated with emotional interference to performance efficiency and response accuracy respectively in the patient group. In addition, relative activation in the dorsolateral prefrontal cortex was observed only in the patient group. These findings suggest that deficit in cognitive modulation over emotional interference in patients with schizophrenia may be explained by failure in suppressing the affective division of the anterior cingulate despite attentional effort. This may provide evidence for the failure in suppressing the bottom-up processing of emotion during cognitive-emotional interaction in schizophrenia.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Behavioral Sciences in Medicine (의학행동과학연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Yeop(김응엽)
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Il Ho(박일호)
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
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