264 401

Cited 62 times in

A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients.

Authors
 Eun Seok Kang  ;  Myoung Soo Kim  ;  Yu Seun Kim  ;  Chul Hoon Kim  ;  Seung Jin Han  ;  Sung Wan Chun  ;  Kyu Yeon Hur  ;  Chung Mo Nam  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Soon Il Kim  ;  Hyun Chul Lee 
Citation
 DIABETES, Vol.57(4) : 1043-1047, 2008 
Journal Title
 DIABETES 
ISSN
 0012-1797 
Issue Date
2008
MeSH
Cation Transport Proteins/genetics* ; DNA/blood ; DNA/genetics ; DNA/isolation & purification ; Diabetes Mellitus/etiology ; Diabetes Mellitus/prevention & control* ; Gene Frequency ; Genetic Variation ; Genotype ; Humans ; Hypoglycemic Agents/therapeutic use ; Kidney Transplantation/physiology* ; Patient Selection ; Polymorphism, Genetic* ; Postoperative Complications/prevention & control ; Retrospective Studies ; Risk Reduction Behavior ; Transplantation, Homologous ; Zinc Transporter 8
Keywords
FPG ; fasting plasma glucose ; HOMA ; homeostasis model assessment ; PTDM ; posttransplantation diabetes mellitus ; SNP ; single nucleotide polymorphism ; ZnT ; zinc transporter
Abstract
OBJECTIVE: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients, and insulin secretory defects play an important role in the pathogenesis of PTDM. The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin secretion. This study investigated the association between genetic variations in the SLC30A8 gene and PTDM in renal allograft recipients. RESEARCH DESIGN AND METHODS: A total of 624 unrelated renal allograft recipients without previously diagnosed diabetes were enrolled. Rs13266634 was genotyped in the cohort, which consisted of 174 posttransplantation diabetic patients and 450 non-posttransplantation diabetic subjects. The genotyping of the SLC30A8 polymorphism was performed using real-time PCR. RESULTS: The prevalence of PTDM was 33.8% in patients carrying the R/R genotype, 26.8% in patients with the R/W genotype, and 19.8% in patients with the W/W genotype. There was a strong association between the number of W-alleles and PTDM risk reduction (P for trend = 0.007). Patients with at least one T-allele showed a decreased risk of PTDM compared with those with the R/R genotype (R/W, risk ratio [RR] 0.78, P = 0.126; W/W, RR 0.52, P = 0.007). The effect of the SLC30A8 genotype remained significant after adjustments for age, sex, body weight gain, and type of immunosuppressant (R/W, hazard ratio [HR] 0.77, P = 0.114; W/W, HR 0.58, P = 0.026). CONCLUSIONS: These data provide evidence that the SLC30A8 rs13266634 gene variation is associated with protection from the development of PTDM in renal allograft recipients.
Files in This Item:
T200800091.pdf Download
DOI
10.2337/db07-0761
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Chun, Sung Wan(전성완)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Han, Seung Jin(한승진)
Hur, Kyu Yeon(허규연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106218
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse