Cited 68 times in
A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients.
DC Field | Value | Language |
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dc.contributor.author | 남정모 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 전성완 | - |
dc.contributor.author | 강은석 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 김명수 | - |
dc.contributor.author | 한승진 | - |
dc.contributor.author | 김순일 | - |
dc.contributor.author | 허규연 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 김철훈 | - |
dc.date.accessioned | 2015-05-19T16:23:26Z | - |
dc.date.available | 2015-05-19T16:23:26Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106218 | - |
dc.description.abstract | OBJECTIVE: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients, and insulin secretory defects play an important role in the pathogenesis of PTDM. The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin secretion. This study investigated the association between genetic variations in the SLC30A8 gene and PTDM in renal allograft recipients. RESEARCH DESIGN AND METHODS: A total of 624 unrelated renal allograft recipients without previously diagnosed diabetes were enrolled. Rs13266634 was genotyped in the cohort, which consisted of 174 posttransplantation diabetic patients and 450 non-posttransplantation diabetic subjects. The genotyping of the SLC30A8 polymorphism was performed using real-time PCR. RESULTS: The prevalence of PTDM was 33.8% in patients carrying the R/R genotype, 26.8% in patients with the R/W genotype, and 19.8% in patients with the W/W genotype. There was a strong association between the number of W-alleles and PTDM risk reduction (P for trend = 0.007). Patients with at least one T-allele showed a decreased risk of PTDM compared with those with the R/R genotype (R/W, risk ratio [RR] 0.78, P = 0.126; W/W, RR 0.52, P = 0.007). The effect of the SLC30A8 genotype remained significant after adjustments for age, sex, body weight gain, and type of immunosuppressant (R/W, hazard ratio [HR] 0.77, P = 0.114; W/W, HR 0.58, P = 0.026). CONCLUSIONS: These data provide evidence that the SLC30A8 rs13266634 gene variation is associated with protection from the development of PTDM in renal allograft recipients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1043~1047 | - |
dc.relation.isPartOf | DIABETES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cation Transport Proteins/genetics* | - |
dc.subject.MESH | DNA/blood | - |
dc.subject.MESH | DNA/genetics | - |
dc.subject.MESH | DNA/isolation & purification | - |
dc.subject.MESH | Diabetes Mellitus/etiology | - |
dc.subject.MESH | Diabetes Mellitus/prevention & control* | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Variation | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoglycemic Agents/therapeutic use | - |
dc.subject.MESH | Kidney Transplantation/physiology* | - |
dc.subject.MESH | Patient Selection | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Postoperative Complications/prevention & control | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Reduction Behavior | - |
dc.subject.MESH | Transplantation, Homologous | - |
dc.subject.MESH | Zinc Transporter 8 | - |
dc.title | A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Seung Jin Han | - |
dc.contributor.googleauthor | Sung Wan Chun | - |
dc.contributor.googleauthor | Kyu Yeon Hur | - |
dc.contributor.googleauthor | Chung Mo Nam | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Soon Il Kim | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.identifier.doi | 10.2337/db07-0761 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03519 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A04302 | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A04343 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J00718 | - |
dc.identifier.eissn | 1939-327X | - |
dc.identifier.pmid | 18162509 | - |
dc.subject.keyword | FPG | - |
dc.subject.keyword | fasting plasma glucose | - |
dc.subject.keyword | HOMA | - |
dc.subject.keyword | homeostasis model assessment | - |
dc.subject.keyword | PTDM | - |
dc.subject.keyword | posttransplantation diabetes mellitus | - |
dc.subject.keyword | SNP | - |
dc.subject.keyword | single nucleotide polymorphism | - |
dc.subject.keyword | ZnT | - |
dc.subject.keyword | zinc transporter | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Chun, Sung Wan | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Han, Seung Jin | - |
dc.contributor.alternativeName | Kim, Soon Il | - |
dc.contributor.alternativeName | Hur, Kyu Yeon | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Chun, Sung Wan | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Han, Seung Jin | - |
dc.contributor.affiliatedAuthor | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Hur, Kyu Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 57 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1043 | - |
dc.citation.endPage | 1047 | - |
dc.identifier.bibliographicCitation | DIABETES, Vol.57(4) : 1043-1047, 2008 | - |
dc.identifier.rimsid | 56284 | - |
dc.type.rims | ART | - |
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