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A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients.

DC Field Value Language
dc.contributor.author남정모-
dc.contributor.author안철우-
dc.contributor.author이현철-
dc.contributor.author전성완-
dc.contributor.author강은석-
dc.contributor.author차봉수-
dc.contributor.author김명수-
dc.contributor.author한승진-
dc.contributor.author김순일-
dc.contributor.author허규연-
dc.contributor.author김유선-
dc.contributor.author김철훈-
dc.date.accessioned2015-05-19T16:23:26Z-
dc.date.available2015-05-19T16:23:26Z-
dc.date.issued2008-
dc.identifier.issn0012-1797-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106218-
dc.description.abstractOBJECTIVE: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients, and insulin secretory defects play an important role in the pathogenesis of PTDM. The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin secretion. This study investigated the association between genetic variations in the SLC30A8 gene and PTDM in renal allograft recipients. RESEARCH DESIGN AND METHODS: A total of 624 unrelated renal allograft recipients without previously diagnosed diabetes were enrolled. Rs13266634 was genotyped in the cohort, which consisted of 174 posttransplantation diabetic patients and 450 non-posttransplantation diabetic subjects. The genotyping of the SLC30A8 polymorphism was performed using real-time PCR. RESULTS: The prevalence of PTDM was 33.8% in patients carrying the R/R genotype, 26.8% in patients with the R/W genotype, and 19.8% in patients with the W/W genotype. There was a strong association between the number of W-alleles and PTDM risk reduction (P for trend = 0.007). Patients with at least one T-allele showed a decreased risk of PTDM compared with those with the R/R genotype (R/W, risk ratio [RR] 0.78, P = 0.126; W/W, RR 0.52, P = 0.007). The effect of the SLC30A8 genotype remained significant after adjustments for age, sex, body weight gain, and type of immunosuppressant (R/W, hazard ratio [HR] 0.77, P = 0.114; W/W, HR 0.58, P = 0.026). CONCLUSIONS: These data provide evidence that the SLC30A8 rs13266634 gene variation is associated with protection from the development of PTDM in renal allograft recipients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1043~1047-
dc.relation.isPartOfDIABETES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCation Transport Proteins/genetics*-
dc.subject.MESHDNA/blood-
dc.subject.MESHDNA/genetics-
dc.subject.MESHDNA/isolation & purification-
dc.subject.MESHDiabetes Mellitus/etiology-
dc.subject.MESHDiabetes Mellitus/prevention & control*-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenetic Variation-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHHypoglycemic Agents/therapeutic use-
dc.subject.MESHKidney Transplantation/physiology*-
dc.subject.MESHPatient Selection-
dc.subject.MESHPolymorphism, Genetic*-
dc.subject.MESHPostoperative Complications/prevention & control-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Reduction Behavior-
dc.subject.MESHTransplantation, Homologous-
dc.subject.MESHZinc Transporter 8-
dc.titleA polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorChul Hoon Kim-
dc.contributor.googleauthorSeung Jin Han-
dc.contributor.googleauthorSung Wan Chun-
dc.contributor.googleauthorKyu Yeon Hur-
dc.contributor.googleauthorChung Mo Nam-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorHyun Chul Lee-
dc.identifier.doi10.2337/db07-0761-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01264-
dc.contributor.localIdA02270-
dc.contributor.localIdA03301-
dc.contributor.localIdA03519-
dc.contributor.localIdA00068-
dc.contributor.localIdA03996-
dc.contributor.localIdA04302-
dc.contributor.localIdA00649-
dc.contributor.localIdA04343-
dc.contributor.localIdA00785-
dc.contributor.localIdA01057-
dc.contributor.localIdA00424-
dc.relation.journalcodeJ00718-
dc.identifier.eissn1939-327X-
dc.identifier.pmid18162509-
dc.subject.keywordFPG-
dc.subject.keywordfasting plasma glucose-
dc.subject.keywordHOMA-
dc.subject.keywordhomeostasis model assessment-
dc.subject.keywordPTDM-
dc.subject.keywordposttransplantation diabetes mellitus-
dc.subject.keywordSNP-
dc.subject.keywordsingle nucleotide polymorphism-
dc.subject.keywordZnT-
dc.subject.keywordzinc transporter-
dc.contributor.alternativeNameNam, Jung Mo-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameChun, Sung Wan-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameHan, Seung Jin-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameHur, Kyu Yeon-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameKim, Chul Hoon-
dc.contributor.affiliatedAuthorNam, Jung Mo-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorChun, Sung Wan-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorHan, Seung Jin-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorHur, Kyu Yeon-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorKim, Chul Hoon-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.rights.accessRightsfree-
dc.citation.volume57-
dc.citation.number4-
dc.citation.startPage1043-
dc.citation.endPage1047-
dc.identifier.bibliographicCitationDIABETES, Vol.57(4) : 1043-1047, 2008-
dc.identifier.rimsid56284-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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