성견 치주 골결손부에서 다양한 합성골 이식재에 의한 치주조직재생효과

Abstract

Several bone graft materials have been studied and developed to regenerate periodontal tissues, and various results have been presented. For a successful bone graft procedure, selection of an appropriate environment and material is as important as developing an ideal material. Therefore, the purpose of this study was to review the articles on various bone graft materials published in department of periodontology, Yonsei university and evaluate its regenerative effect in different periodontal defect models. 14 articles, experimented with various bone graft materials in beagle dogs published in department of periodontology, Yonsei university were used. Comparison was done with the results of histomorphometric analysis according to type of bone graft material and defect morphology. Calcium showed greater bone formation when used in combination with Emdogain®, DFDBA, DBM than in sole application. There was significant increase in cementum regeneration with paste-type calcium sulfate. Bioactive glass presented less apical migration of junctional epithelium when applied in 1-wall intrabony defect model. However, there were no significant change in new bone formation and cementum regeneration. CPG graft material was effective in cementum regeneration in 1-wall intrabony defects with enhanced bone formation when combined with chitosan membrane. New cementum regeneration was less effective in 1 wall periodontal intrabony defect model than in 3 wall intrabony defect. In concerning the difference of experimental methods and the histologic processing, there are limitations in comparing different bone graft materials directly. Therefore, in order to compare, strict standardization of the defect model and method is necessary. Moreover, a protocol for an adequate clinical application of the materials according to its characteristics is also needed to be evaluated in the future.