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Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.

Authors
 JH Choi  ;  MG Lee  ;  J-Y Cho  ;  J-E Lee  ;  KH Kim  ;  K Park 
Citation
 Clinical Pharmacology & Therapeutics, Vol.83(2) : 251-257, 2008 
Journal Title
 Clinical Pharmacology & Therapeutics 
ISSN
 0009-9236 
Issue Date
2008
MeSH
Administration, Oral ; Area Under Curve ; Asian Continental Ancestry Group/genetics* ; Fluorobenzenes/administration & dosage ; Fluorobenzenes/blood ; Fluorobenzenes/pharmacokinetics* ; Gene Frequency ; Genotype ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/blood ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics* ; Korea ; Lactones/administration & dosage ; Lactones/blood ; Lactones/pharmacokinetics* ; Organic Anion Transporters/genetics* ; Organic Anion Transporters/metabolism ; Phenotype ; Polymorphism, Genetic* ; Pyrimidines/administration & dosage ; Pyrimidines/blood ; Pyrimidines/pharmacokinetics* ; Rosuvastatin Calcium ; Solute Carrier Organic Anion Transporter Family Member 1b1 ; Sulfonamides/administration & dosage ; Sulfonamides/blood ; Sulfonamides/pharmacokinetics*
Keywords
Administration, Oral ; Area Under Curve ; Asian Continental Ancestry Group/genetics* ; Fluorobenzenes/administration & dosage ; Fluorobenzenes/blood ; Fluorobenzenes/pharmacokinetics* ; Gene Frequency ; Genotype ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/blood ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics* ; Korea ; Lactones/administration & dosage ; Lactones/blood ; Lactones/pharmacokinetics* ; Organic Anion Transporters/genetics* ; Organic Anion Transporters/metabolism ; Phenotype ; Polymorphism, Genetic* ; Pyrimidines/administration & dosage ; Pyrimidines/blood ; Pyrimidines/pharmacokinetics* ; Rosuvastatin Calcium ; Solute Carrier Organic Anion Transporter Family Member 1b1 ; Sulfonamides/administration & dosage ; Sulfonamides/blood ; Sulfonamides/pharmacokinetics*
Abstract
This study was carried out to determine whether polymorphisms of organic anion-transporting polypeptide 1B1 (OATP1B1) have an effect on rosuvastatin pharmacokinetics in Koreans. Among 200 subjects genotyped for OATP1B1 c.388A>G, and c.521T>C, 30 subjects were selected for the rosuvastatin pharmacokinetic study. The area under the concentration-time curve for 0 to infinity (AUC(0-infinity)) of rosuvastatin for group 1 (*1a/*1a, *1a/*1b, *1b/*1b), group 2 (*1a/*15, *1b/*15), and group 3 (*15/*15) were 111+/-49.3, 126+/-45.2, and 191+/-31.0 ng h/ml, respectively, with significant differences among the three groups (P=0.0429) and between *15/*15 and the other groups (P=0.0181). The maximum plasma concentration (Cmax) also showed a significant difference between *15/*15 and the other groups (P=0.0181). There were no significant differences in rosuvastatin-lactone pharmacokinetics among the three groups. The pharmacokinetic exposure of rosuvastatin was higher in the OATP1B1*15/*15 subjects than the others, suggesting a potential association between the OATP1B1 genetic polymorphisms and altered rosuvastatin pharmacokinetics in Korean populations.
Full Text
http://www.nature.com/clpt/journal/v83/n2/full/6100267a.html
DOI
10.1038/sj.clpt.6100267
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
Park, Kyungsoo(박경수) ORCID logo https://orcid.org/0000-0002-6972-1143
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106133
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