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Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.

DC FieldValueLanguage
dc.contributor.author김경환-
dc.contributor.author박경수-
dc.contributor.author이민구-
dc.date.accessioned2015-05-19T16:20:37Z-
dc.date.available2015-05-19T16:20:37Z-
dc.date.issued2008-
dc.identifier.issn0009-9236-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106133-
dc.description.abstractThis study was carried out to determine whether polymorphisms of organic anion-transporting polypeptide 1B1 (OATP1B1) have an effect on rosuvastatin pharmacokinetics in Koreans. Among 200 subjects genotyped for OATP1B1 c.388A>G, and c.521T>C, 30 subjects were selected for the rosuvastatin pharmacokinetic study. The area under the concentration-time curve for 0 to infinity (AUC(0-infinity)) of rosuvastatin for group 1 (*1a/*1a, *1a/*1b, *1b/*1b), group 2 (*1a/*15, *1b/*15), and group 3 (*15/*15) were 111+/-49.3, 126+/-45.2, and 191+/-31.0 ng h/ml, respectively, with significant differences among the three groups (P=0.0429) and between *15/*15 and the other groups (P=0.0181). The maximum plasma concentration (Cmax) also showed a significant difference between *15/*15 and the other groups (P=0.0181). There were no significant differences in rosuvastatin-lactone pharmacokinetics among the three groups. The pharmacokinetic exposure of rosuvastatin was higher in the OATP1B1*15/*15 subjects than the others, suggesting a potential association between the OATP1B1 genetic polymorphisms and altered rosuvastatin pharmacokinetics in Korean populations.-
dc.description.statementOfResponsibilityopen-
dc.format.extent251~257-
dc.relation.isPartOfCLINICAL PHARMACOLOGY & THERAPEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHArea Under Curve-
dc.subject.MESHAsian Continental Ancestry Group/genetics*-
dc.subject.MESHFluorobenzenes/administration & dosage-
dc.subject.MESHFluorobenzenes/blood-
dc.subject.MESHFluorobenzenes/pharmacokinetics*-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/blood-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics*-
dc.subject.MESHKorea-
dc.subject.MESHLactones/administration & dosage-
dc.subject.MESHLactones/blood-
dc.subject.MESHLactones/pharmacokinetics*-
dc.subject.MESHOrganic Anion Transporters/genetics*-
dc.subject.MESHOrganic Anion Transporters/metabolism-
dc.subject.MESHPhenotype-
dc.subject.MESHPolymorphism, Genetic*-
dc.subject.MESHPyrimidines/administration & dosage-
dc.subject.MESHPyrimidines/blood-
dc.subject.MESHPyrimidines/pharmacokinetics*-
dc.subject.MESHRosuvastatin Calcium-
dc.subject.MESHSolute Carrier Organic Anion Transporter Family Member 1b1-
dc.subject.MESHSulfonamides/administration & dosage-
dc.subject.MESHSulfonamides/blood-
dc.subject.MESHSulfonamides/pharmacokinetics*-
dc.titleInfluence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorJH Choi-
dc.contributor.googleauthorMG Lee-
dc.contributor.googleauthorJ-Y Cho-
dc.contributor.googleauthorJ-E Lee-
dc.contributor.googleauthorKH Kim-
dc.contributor.googleauthorK Park-
dc.identifier.doi10.1038/sj.clpt.6100267-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00311-
dc.contributor.localIdA01422-
dc.contributor.localIdA02781-
dc.relation.journalcodeJ00608-
dc.identifier.eissn1532-6535-
dc.identifier.pmid17568401-
dc.identifier.urlhttp://www.nature.com/clpt/journal/v83/n2/full/6100267a.html-
dc.subject.keywordAdministration, Oral-
dc.subject.keywordArea Under Curve-
dc.subject.keywordAsian Continental Ancestry Group/genetics*-
dc.subject.keywordFluorobenzenes/administration & dosage-
dc.subject.keywordFluorobenzenes/blood-
dc.subject.keywordFluorobenzenes/pharmacokinetics*-
dc.subject.keywordGene Frequency-
dc.subject.keywordGenotype-
dc.subject.keywordHumans-
dc.subject.keywordHydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage-
dc.subject.keywordHydroxymethylglutaryl-CoA Reductase Inhibitors/blood-
dc.subject.keywordHydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics*-
dc.subject.keywordKorea-
dc.subject.keywordLactones/administration & dosage-
dc.subject.keywordLactones/blood-
dc.subject.keywordLactones/pharmacokinetics*-
dc.subject.keywordOrganic Anion Transporters/genetics*-
dc.subject.keywordOrganic Anion Transporters/metabolism-
dc.subject.keywordPhenotype-
dc.subject.keywordPolymorphism, Genetic*-
dc.subject.keywordPyrimidines/administration & dosage-
dc.subject.keywordPyrimidines/blood-
dc.subject.keywordPyrimidines/pharmacokinetics*-
dc.subject.keywordRosuvastatin Calcium-
dc.subject.keywordSolute Carrier Organic Anion Transporter Family Member 1b1-
dc.subject.keywordSulfonamides/administration & dosage-
dc.subject.keywordSulfonamides/blood-
dc.subject.keywordSulfonamides/pharmacokinetics*-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.alternativeNamePark, Kyung Soo-
dc.contributor.alternativeNameLee, Min Goo-
dc.contributor.affiliatedAuthorKim, Kyung Hwan-
dc.contributor.affiliatedAuthorPark, Kyung Soo-
dc.contributor.affiliatedAuthorLee, Min Goo-
dc.rights.accessRightsnot free-
dc.citation.volume83-
dc.citation.number2-
dc.citation.startPage251-
dc.citation.endPage257-
dc.identifier.bibliographicCitationCLINICAL PHARMACOLOGY & THERAPEUTICS, Vol.83(2) : 251-257, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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