Cited 116 times in
Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경환 | - |
dc.contributor.author | 박경수 | - |
dc.contributor.author | 이민구 | - |
dc.date.accessioned | 2015-05-19T16:20:37Z | - |
dc.date.available | 2015-05-19T16:20:37Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0009-9236 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106133 | - |
dc.description.abstract | This study was carried out to determine whether polymorphisms of organic anion-transporting polypeptide 1B1 (OATP1B1) have an effect on rosuvastatin pharmacokinetics in Koreans. Among 200 subjects genotyped for OATP1B1 c.388A>G, and c.521T>C, 30 subjects were selected for the rosuvastatin pharmacokinetic study. The area under the concentration-time curve for 0 to infinity (AUC(0-infinity)) of rosuvastatin for group 1 (*1a/*1a, *1a/*1b, *1b/*1b), group 2 (*1a/*15, *1b/*15), and group 3 (*15/*15) were 111+/-49.3, 126+/-45.2, and 191+/-31.0 ng h/ml, respectively, with significant differences among the three groups (P=0.0429) and between *15/*15 and the other groups (P=0.0181). The maximum plasma concentration (Cmax) also showed a significant difference between *15/*15 and the other groups (P=0.0181). There were no significant differences in rosuvastatin-lactone pharmacokinetics among the three groups. The pharmacokinetic exposure of rosuvastatin was higher in the OATP1B1*15/*15 subjects than the others, suggesting a potential association between the OATP1B1 genetic polymorphisms and altered rosuvastatin pharmacokinetics in Korean populations. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 251~257 | - |
dc.relation.isPartOf | CLINICAL PHARMACOLOGY & THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration, Oral | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Fluorobenzenes/administration & dosage | - |
dc.subject.MESH | Fluorobenzenes/blood | - |
dc.subject.MESH | Fluorobenzenes/pharmacokinetics* | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/blood | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Lactones/administration & dosage | - |
dc.subject.MESH | Lactones/blood | - |
dc.subject.MESH | Lactones/pharmacokinetics* | - |
dc.subject.MESH | Organic Anion Transporters/genetics* | - |
dc.subject.MESH | Organic Anion Transporters/metabolism | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Pyrimidines/administration & dosage | - |
dc.subject.MESH | Pyrimidines/blood | - |
dc.subject.MESH | Pyrimidines/pharmacokinetics* | - |
dc.subject.MESH | Rosuvastatin Calcium | - |
dc.subject.MESH | Solute Carrier Organic Anion Transporter Family Member 1b1 | - |
dc.subject.MESH | Sulfonamides/administration & dosage | - |
dc.subject.MESH | Sulfonamides/blood | - |
dc.subject.MESH | Sulfonamides/pharmacokinetics* | - |
dc.title | Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | JH Choi | - |
dc.contributor.googleauthor | MG Lee | - |
dc.contributor.googleauthor | J-Y Cho | - |
dc.contributor.googleauthor | J-E Lee | - |
dc.contributor.googleauthor | KH Kim | - |
dc.contributor.googleauthor | K Park | - |
dc.identifier.doi | 10.1038/sj.clpt.6100267 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00311 | - |
dc.contributor.localId | A01422 | - |
dc.contributor.localId | A02781 | - |
dc.relation.journalcode | J00608 | - |
dc.identifier.eissn | 1532-6535 | - |
dc.identifier.pmid | 17568401 | - |
dc.identifier.url | http://www.nature.com/clpt/journal/v83/n2/full/6100267a.html | - |
dc.subject.keyword | Administration, Oral | - |
dc.subject.keyword | Area Under Curve | - |
dc.subject.keyword | Asian Continental Ancestry Group/genetics* | - |
dc.subject.keyword | Fluorobenzenes/administration & dosage | - |
dc.subject.keyword | Fluorobenzenes/blood | - |
dc.subject.keyword | Fluorobenzenes/pharmacokinetics* | - |
dc.subject.keyword | Gene Frequency | - |
dc.subject.keyword | Genotype | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage | - |
dc.subject.keyword | Hydroxymethylglutaryl-CoA Reductase Inhibitors/blood | - |
dc.subject.keyword | Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics* | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | Lactones/administration & dosage | - |
dc.subject.keyword | Lactones/blood | - |
dc.subject.keyword | Lactones/pharmacokinetics* | - |
dc.subject.keyword | Organic Anion Transporters/genetics* | - |
dc.subject.keyword | Organic Anion Transporters/metabolism | - |
dc.subject.keyword | Phenotype | - |
dc.subject.keyword | Polymorphism, Genetic* | - |
dc.subject.keyword | Pyrimidines/administration & dosage | - |
dc.subject.keyword | Pyrimidines/blood | - |
dc.subject.keyword | Pyrimidines/pharmacokinetics* | - |
dc.subject.keyword | Rosuvastatin Calcium | - |
dc.subject.keyword | Solute Carrier Organic Anion Transporter Family Member 1b1 | - |
dc.subject.keyword | Sulfonamides/administration & dosage | - |
dc.subject.keyword | Sulfonamides/blood | - |
dc.subject.keyword | Sulfonamides/pharmacokinetics* | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.alternativeName | Park, Kyung Soo | - |
dc.contributor.alternativeName | Lee, Min Goo | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | Park, Kyung Soo | - |
dc.contributor.affiliatedAuthor | Lee, Min Goo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 83 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 251 | - |
dc.citation.endPage | 257 | - |
dc.identifier.bibliographicCitation | CLINICAL PHARMACOLOGY & THERAPEUTICS, Vol.83(2) : 251-257, 2008 | - |
dc.identifier.rimsid | 54741 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.