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Clinical Implications of Serum Retinol-Binding Protein 4 in Asthmatic Children

Authors
 Yeo Hoon Park  ;  Kyung Won Kim  ;  Kyung Eun Lee  ;  Eun Soo Kim  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.24(6) : 1010-1014, 2009 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2009
MeSH
Asthma*/blood ; Asthma*/immunology ; Bronchial Hyperreactivity/blood ; Bronchial Hyperreactivity/immunology ; Bronchial Provocation Tests ; Child ; Female ; Humans ; Male ; Obesity/blood ; Obesity/immunology ; Retinol-Binding Proteins, Plasma/metabolism*
Keywords
Asthma ; Child ; Pulmonary Function ; Retinol-Binding Protein 4
Abstract
Recently the prevalence of both asthma and obesity have increased substantially in many countries. The aim of this study was to evaluate the role of retinol-binding protein (RBP) 4 in childhood asthma and its association with atopy markers, pulmonary function, and bronchial hyperresponsiveness in relation to obesity. We studied 160 children between the ages 6 to 10 yr, including 122 asthmatics and 38 controls. The body mass index, pulmonary function tests, and methacholine challenge tests were measured on the same day. Total eosinophil count, serum total IgE, serum eosinophil cationic protein, and serum RBP4 were measured in all subjects. There was no difference in serum RBP4 levels between the asthmatics and the control group. In all subjects or subgroups, serum RBP4 was not associated with total eosinophil count, serum total IgE, serum eosinophil cationic protein, or PC20. There was no relationship between serum RBP4 and pulmonary function in female asthmatics. Forced expiratory volume in 1 second/forced vital capacity (FVC) and forced expiratory flow between 25% and 75% of FVC contributed to serum RBP4 in male asthmatics. Our findings show an association between RBP4 and pulmonary function in prepubertal male asthmatics. This relationship may indirectly affect the high prevalence of childhood asthma in males
Files in This Item:
T200905008.pdf Download
DOI
10.3346/jkms.2009.24.6.1010
Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Kim, Eun Soo(김은수)
Park, Yeo Hoon(박여훈)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Lee, Kyung Eun(이경은)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105667
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