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Comparative study of resection and radiofrequency ablation in the treatment of solitary colorectal liver metastases

Authors
 Hyuk Hur  ;  Yong Taek Ko  ;  Byung Soh Min  ;  Kyung Sik Kim  ;  Jin Sub Choi  ;  Seung Kook Sohn  ;  Chang Hwan Cho  ;  Heung Kyu Ko  ;  Jong Tai Lee  ;  Nam Kyu Kim 
Citation
 AMERICAN JOURNAL OF SURGERY, Vol.197(6) : 728-736, 2009 
Journal Title
 AMERICAN JOURNAL OF SURGERY 
ISSN
 0002-9610 
Issue Date
2009
MeSH
Adult ; Aged ; Catheter Ablation* ; Colorectal Neoplasms/pathology* ; Female ; Hepatectomy* ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary* ; Liver Neoplasms/surgery* ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate
Keywords
Solitary colorectal liver metastases ; Radiofrequency ablation ; Hepatic resection ; Recurrence ; Survival
Abstract
BACKGROUND: We compared outcomes in patients with solitary colorectal liver metastases treated by either hepatic resection (HR) or radiofrequency ablation (RFA). METHODS: A retrospective analysis from a prospective database was performed on 67 consecutive patients with solitary colorectal liver metastases treated by either HR or RFA. RESULTS: Forty-two patients underwent HR and 25 patients underwent RFA. The 5-year overall and local recurrence-free survival rates after HR (50.1% and 89.7%, respectively) were higher than after RFA (25.5% and 69.7%, respectively) (P = .0263 and .028, respectively). In small tumors less than 3 cm (n = 38), the 5-year survival rates between HR and RFA were similar, including overall (56.1% vs 55.4%, P = .451) and local recurrence-free (95.7% vs 85.6%, P = .304) survival rates. On multivariate analysis, tumor size, metastases treatment, and primary node status were significant prognostic factors. CONCLUSIONS: HR had better outcomes than RFA for recurrence and survival after treatment of solitary colorectal liver metastases. However, in tumors smaller than 3 cm, RFA can be recommended as an alternative treatment to patients who are not candidates for surgery because the liver metastases is poorly located anatomically, the functional hepatic reserve after a resection would be insufficient, the patient's comorbidity inhibits a major surgery, or extrahepatic metastases are present.
Full Text
http://www.sciencedirect.com/science/article/pii/S0002961008005369
DOI
10.1016/j.amjsurg.2008.04.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Ko, Yong Taek(고용택)
Ko, Heung Kyu(고흥규)
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Sohn, Seung Kook(손승국)
Lee, Jong Tae(이종태)
Cho, Chang Hwan(조장환)
Choi, Jin Sub(최진섭)
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105272
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