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Significance of sonographic characterization for managing subcentimeter thyroid nodules

Authors
 JIN YOUNG KWAK  ;  EUN-KYUNG KIM  ;  MIN JUNG KIM  ;  EUN JU SON 
Citation
 ACTA RADIOLOGICA, Vol.50(8) : 917-923, 2009 
Journal Title
 ACTA RADIOLOGICA 
ISSN
 0284-1851 
Issue Date
2009
MeSH
Adolescent ; Adult ; Aged ; Biopsy, Fine-Needle ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Predictive Value of Tests ; Sensitivity and Specificity ; Thyroid Nodule/diagnostic imaging* ; Thyroid Nodule/pathology ; Ultrasonography
Keywords
Thyroid ; thyroid carcinoma ; ultrasonography
Abstract
BACKGROUND: Ultrasonography (US) is increasingly able to detect thyroid nodules, and the differentiation between malignant and benign nodules has been raising issues among both clinicians and patients, especially patients with non-palpable small nodules. It is important to diagnose thyroid cancer at an early stage, because it may reduce the risk of disease recurrence and possible mortality. PURPOSE: To evaluate the diagnostic accuracy of malignant sonographic features of subcentimeter thyroid nodules. MATERIAL AND METHODS: This study examined 815 subcentimeter thyroid nodules in 815 patients. A final diagnosis was determined using fine-needle aspiration biopsy (FNAB) or postoperative pathologic findings. Logistic regression tests were used to evaluate statistical relationships between US findings and thyroid carcinoma. Results: Of 534 lesions that showed suspicious US findings, 472 (88.4%) revealed malignancy upon cytopathology. Two hundred eighty-one lesions showed probably benign findings on US, and only 23 (8.2%) were malignant. Sensitivity, specificity, positive predictive value, and negative predictive value of US were 95.4%, 80.6%, 88.4%, and 91.8%, respectively. There was a significant difference between the two US groups in the percentages of malignancy, according to logistic regression analysis. CONCLUSION: Our results demonstrate that this system of US classification can efficiently differentiate malignant subcentimeter nodules from benign nodules. Suspicious sonographic features can be useful criteria to decide whether a nodule should receive FNAB
Full Text
http://acr.sagepub.com/content/50/8/917.abstract
DOI
10.1080/02841850903062724
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105266
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