0 251

Cited 28 times in

Outcome of surgical treatment in non-lesional intractable childhood epilepsy

Authors
 Joo Hee Seo  ;  Byoung Ho Noh  ;  Joon Soo Lee  ;  Dong Suk Kim  ;  Seung Koo Lee  ;  Tae Seung Kim  ;  Se Hoon Kim  ;  Hoon Chul Kang  ;  Heung Dong Kim 
Citation
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.18(9) : 625-629, 2009 
Journal Title
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 
ISSN
 1059-1311 
Issue Date
2009
MeSH
Child ; Child, Preschool ; Epilepsy/diagnostic imaging ; Epilepsy/pathology ; Epilepsy/surgery* ; Female ; Humans ; Infant ; Male ; Neurosurgical Procedures* ; Positron-Emission Tomography ; Retrospective Studies ; Tomography, Emission-Computed, Single-Photon ; Treatment Outcome
Keywords
Intractable childhood epilepsy ; Epilepsy surgery ; Normal magnetic resonance imaging ; Surgical outcome
Abstract
PURPOSE: The aim of this study is to investigate seizure outcomes following epilepsy surgery in non-lesional neocortical pediatric epilepsy. METHODS: We performed a retrospective study on 27 patients with intractable childhood epilepsy who received epilepsy surgery between 1999 and 2006 at Sang-gye Paik Hospital and Severance Children's Hospital. None of the patients had any detectable lesions on MRI. Surgical outcome was assessed at least 2 years postoperatively; clinical characteristics, surgical outcome, pathologic findings, types of surgery, localizing features on SPECT, FDG-PET, and long-term video-EEG were reviewed. RESULTS: Eighteen patients (67%) demonstrated an Engel class I outcome postoperatively. The mean follow-up duration was 4.3 years (range, 2.2-9 years). Eighteen out of 27 cases (67%) showed focal localizing features on ictal SPECT, and 21 of 27 cases (78%) showed abnormal findings on PET. Single lobectomy was the most common procedure, and was performed in 20 patients (74%). Multilobar resection was performed in seven patients (26%). Cortical dysplasia was the most common finding during pathological examination, and was observed in 15 (56%) cases. In addition, gliosis was found in two patients (7%) and non-specific pathological findings were described in 10 patients (37%). CONCLUSIONS: In children with intractable epilepsy and a MRI demonstrating no abnormal lesions, epileptic surgery should be strongly considered when cortical pathology can be identified from other studies
Full Text
http://www.sciencedirect.com/science/article/pii/S1059131109001411
DOI
10.1016/j.seizure.2009.07.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Dong Seok(김동석)
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Kim, Tai Seung(김태승)
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105096
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse