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Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 (rhGDF-5) in an absorbable collagen sponge carrier into one-wall intrabony defects in dogs: a dose-range study.

Authors
 Tae-Gyun Kim  ;  Ulf M. E. Wikesjo  ;  Kyoo-Sung Cho  ;  Jung-Kiu Chai  ;  Susanne D. Pippig  ;  Michael Siedler  ;  Chong-Kwan Kim 
Citation
 JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.36(7) : 589-597, 2009 
Journal Title
 JOURNAL OF CLINICAL PERIODONTOLOGY 
ISSN
 0303-6979 
Issue Date
2009
MeSH
Absorbable Implants* ; Alveolar Process/drug effects* ; Alveolar Process/surgery ; Analysis of Variance ; Animals ; Bone Regeneration/drug effects* ; Bone Regeneration/physiology ; Collagen ; Dental Cementum/drug effects* ; Dental Cementum/surgery ; Dogs ; Dose-Response Relationship, Drug ; Growth Differentiation Factor 5/administration & dosage* ; Growth Differentiation Factor 5/physiology ; Humans ; Male ; Mandible ; Periodontal Ligament/drug effects* ; Periodontal Ligament/physiology ; Recombinant Proteins/administration & dosage ; Single-Blind Method ; Surgical Sponges ; Wound Healing/drug effects ; Wound Healing/physiology
Keywords
absorbable collagen sponge ; dog ; periodontal regeneration ; rhGDF‐5 ; tissue engineering
Abstract
AIM: Recombinant human growth/differentiation factor-5 (rhGDF-5) is being evaluated as a candidate therapy in support of periodontal regeneration. The objective of this study was to evaluate cementum and alveolar bone formation, and aberrant healing events following surgical implantation of rhGDF-5 in an absorbable collagen sponge (ACS) carrier using an established periodontal defect model. MATERIALS AND METHODS: Bilateral 4 x 5 mm (width x depth), one-wall, critical-size, intrabony periodontal defects were surgically created at the mandibular second and fourth pre-molar teeth in 15 Beagle dogs. Five animals received 1 microg/defect and five animals 20 microg/defect rhGDF-5 in unilateral defect sites. Contralateral sites received treatments reported elsewhere. Five animals received rhGDF-5/ACS with 0 (buffer control) and 100 microg/defect rhGDF-5 in contralateral defect sites. The animals were euthanized at 8 weeks post-surgery for histologic and histometric evaluation. RESULTS: Surgical implantation of rhGDF-5 stimulated significant periodontal regeneration. Cementum formation was significantly enhanced in sites implanted with rhGDF-5 (1 and 100 microg) compared with control (p<0.05). Similarly, bone formation height was significantly greater in sites receiving rhGDF-5 (1 and 100 microg) compared with control (p<0.05). There were no significant or remarkable differences in bone and cementum formation within the selected dose interval (1, 20 and 100 microg rhGDF-5). None of the control or the rhGDF-5 sites exhibited root resorption, ankylosis, or other aberrant tissue reactions. CONCLUSION: Surgical implantation of rhGDF-5/ACS may be used safely to support periodontal wound healing/regeneration in intrabony periodontal defects without complications
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2009.01420.x/abstract
DOI
10.1111/j.1600-051X.2009.01420.x
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Tae Gyun(김태균)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Chai, Jung Kyu(채중규)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104684
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