Cited 55 times in
Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 (rhGDF-5) in an absorbable collagen sponge carrier into one-wall intrabony defects in dogs: a dose-range study.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조규성 | - |
dc.contributor.author | 채중규 | - |
dc.contributor.author | 김종관 | - |
dc.contributor.author | 김태균 | - |
dc.date.accessioned | 2015-04-24T17:03:39Z | - |
dc.date.available | 2015-04-24T17:03:39Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104684 | - |
dc.description.abstract | AIM: Recombinant human growth/differentiation factor-5 (rhGDF-5) is being evaluated as a candidate therapy in support of periodontal regeneration. The objective of this study was to evaluate cementum and alveolar bone formation, and aberrant healing events following surgical implantation of rhGDF-5 in an absorbable collagen sponge (ACS) carrier using an established periodontal defect model. MATERIALS AND METHODS: Bilateral 4 x 5 mm (width x depth), one-wall, critical-size, intrabony periodontal defects were surgically created at the mandibular second and fourth pre-molar teeth in 15 Beagle dogs. Five animals received 1 microg/defect and five animals 20 microg/defect rhGDF-5 in unilateral defect sites. Contralateral sites received treatments reported elsewhere. Five animals received rhGDF-5/ACS with 0 (buffer control) and 100 microg/defect rhGDF-5 in contralateral defect sites. The animals were euthanized at 8 weeks post-surgery for histologic and histometric evaluation. RESULTS: Surgical implantation of rhGDF-5 stimulated significant periodontal regeneration. Cementum formation was significantly enhanced in sites implanted with rhGDF-5 (1 and 100 microg) compared with control (p<0.05). Similarly, bone formation height was significantly greater in sites receiving rhGDF-5 (1 and 100 microg) compared with control (p<0.05). There were no significant or remarkable differences in bone and cementum formation within the selected dose interval (1, 20 and 100 microg rhGDF-5). None of the control or the rhGDF-5 sites exhibited root resorption, ankylosis, or other aberrant tissue reactions. CONCLUSION: Surgical implantation of rhGDF-5/ACS may be used safely to support periodontal wound healing/regeneration in intrabony periodontal defects without complications | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 589~597 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PERIODONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorbable Implants* | - |
dc.subject.MESH | Alveolar Process/drug effects* | - |
dc.subject.MESH | Alveolar Process/surgery | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Regeneration/drug effects* | - |
dc.subject.MESH | Bone Regeneration/physiology | - |
dc.subject.MESH | Collagen | - |
dc.subject.MESH | Dental Cementum/drug effects* | - |
dc.subject.MESH | Dental Cementum/surgery | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Growth Differentiation Factor 5/administration & dosage* | - |
dc.subject.MESH | Growth Differentiation Factor 5/physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mandible | - |
dc.subject.MESH | Periodontal Ligament/drug effects* | - |
dc.subject.MESH | Periodontal Ligament/physiology | - |
dc.subject.MESH | Recombinant Proteins/administration & dosage | - |
dc.subject.MESH | Single-Blind Method | - |
dc.subject.MESH | Surgical Sponges | - |
dc.subject.MESH | Wound Healing/drug effects | - |
dc.subject.MESH | Wound Healing/physiology | - |
dc.title | Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 (rhGDF-5) in an absorbable collagen sponge carrier into one-wall intrabony defects in dogs: a dose-range study. | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Tae-Gyun Kim | - |
dc.contributor.googleauthor | Ulf M. E. Wikesjo | - |
dc.contributor.googleauthor | Kyoo-Sung Cho | - |
dc.contributor.googleauthor | Jung-Kiu Chai | - |
dc.contributor.googleauthor | Susanne D. Pippig | - |
dc.contributor.googleauthor | Michael Siedler | - |
dc.contributor.googleauthor | Chong-Kwan Kim | - |
dc.identifier.doi | 10.1111/j.1600-051X.2009.01420.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A04024 | - |
dc.contributor.localId | A01067 | - |
dc.contributor.localId | A00914 | - |
dc.relation.journalcode | J01337 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.pmid | 19538332 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2009.01420.x/abstract | - |
dc.subject.keyword | absorbable collagen sponge | - |
dc.subject.keyword | dog | - |
dc.subject.keyword | periodontal regeneration | - |
dc.subject.keyword | rhGDF‐5 | - |
dc.subject.keyword | tissue engineering | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Chai, Jung Kyu | - |
dc.contributor.alternativeName | Kim, Chong Kwan | - |
dc.contributor.alternativeName | Kim, Tae Gyun | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Chai, Jung Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Tae Gyun | - |
dc.contributor.affiliatedAuthor | Kim, Chong Kwan | - |
dc.citation.volume | 36 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 589 | - |
dc.citation.endPage | 597 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.36(7) : 589-597, 2009 | - |
dc.identifier.rimsid | 52859 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.