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Microporous PTFE membrane on bone regeneration in rat calvarial defects

 Jung-Yoo Choi  ;  Yoo-Jung Um  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Kyoo-Sung Cho  ;  Jung Kiu Chai  ;  Yong Keun Lee  ;  Chong Kwan Kim  ;  Seong Ho Choi 
 Biomaterials Research (생체재료학회지), Vol.13(3) : 93-98, 2009 
Journal Title
Biomaterials Research(생체재료학회지)
Issue Date
bone ; microporous PTFE membrane ; regeneration ; rats
Novel membrane is always being developed for guided bone regeneration(GBR). The purpose of this study was to
evaluate the microporous polytetrafluoroethylene(PTFE) membrane on bone regeneration in rat calvarial defects.
Thirty male Sprague-Dawley rats were used in 3 groups. One was the control group with no material used, another
was the positive control group which used the resorbable membrane, collagen and the other was the experimental
group which used the microporous PTFE membrane. The barrier membranes were applied in the surgically created
standardized 8 mm cranial defect. The rats were sacrificed at 2 or 8 weeks. The amount of bone regeneration was
assessed histologically and histomorphometrically. The bone formation increased under both barrier membranes
compared with the control group. In terms of time, more bone was filled in 8 weeks than 2 weeks. Better bone
formation was seen in defects protected by a microporous PTFE barrier when compared with the control and collagen
group. It can be concluded that microporous PTFE membrane is effective in bone regeneration for its biocompatibility,
bone formation enhancement, ease of use and space maintenance
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2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Um, Yoo Jung(엄유정)
Lee, Yong Keun(이용근)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Chai, Jung Kyu(채중규)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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