Microporous PTFE membrane on bone regeneration in rat calvarial defects

Abstract

Novel membrane is always being developed for guided bone regeneration(GBR). The purpose of this study was to evaluate the microporous polytetrafluoroethylene(PTFE) membrane on bone regeneration in rat calvarial defects. Thirty male Sprague-Dawley rats were used in 3 groups. One was the control group with no material used, another was the positive control group which used the resorbable membrane, collagen and the other was the experimental group which used the microporous PTFE membrane. The barrier membranes were applied in the surgically created standardized 8 mm cranial defect. The rats were sacrificed at 2 or 8 weeks. The amount of bone regeneration was assessed histologically and histomorphometrically. The bone formation increased under both barrier membranes compared with the control group. In terms of time, more bone was filled in 8 weeks than 2 weeks. Better bone formation was seen in defects protected by a microporous PTFE barrier when compared with the control and collagen group. It can be concluded that microporous PTFE membrane is effective in bone regeneration for its biocompatibility, bone formation enhancement, ease of use and space maintenance