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Expression of p63 during Early Craniofacial Development of the Mouse Embryo

Other Titles
 생쥐의 초기 두개악안면 발생 중 p63의 발현 양상 
Authors
 호소야 아키히로  ;  이종민  ;  김지연  ;  정한성  ;  조성원 
Citation
 Development & Reproduction (발생과 생식), Vol.13(2) : 89-95, 2009 
Journal Title
Development & Reproduction(발생과 생식)
ISSN
 1226-6752 
Issue Date
2009
Keywords
p63 ; Tooth development ; Dental epithelium ; Hertwig's epithelial root sheath ; Epithelial cell rests of Malassez
Abstract
p63 has been demonstrated to localize in stem cells and precursor cells of various epithelial tissues previously, but the localization of p63 throughout tooth formation, particularly during the enamel and root formation stages, remains to be adequately characterized. Therefore, in this study, we have demonstrated, via immunohistochemical methods, that p63 is ubiquitously expressed in the dental epithelium during tooth development. p63 was detected in the basal and suprabasal layers of the epithelia, including the skin, hair follicles, oral mucosa, and submandibular ducts. However, in the tooth region, all cells of the dental lamina, enamel organ, Hertwig's epithelial root sheath (HERS), and epithelial cell rests of Malassez (ERM) evidenced immunoreactivity for p63. These results indicate that p63 may perform different roles, other than stem cell maintenance, in tooth development
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104572
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