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Amorphous Calcium Polyphosphate Bone Regenerative Materials Based on Calcium Phosphate Glass

Authors
 Byung Hyun Lee  ;  Min Chul Kim  ;  Seong Ho Choi  ;  Yong Keun Lee 
Citation
 Key Engineering Materials, Vol.396~398 : 209-212, 2009 
Journal Title
Key Engineering Materials
ISSN
 1013-9826 
Issue Date
2009
Keywords
Amorphous calcium polyphosphate ; Calcium phosphate glass ; Non-crystalline material ; Bone regenerative material
Abstract
We developed new calcium phosphate bone substitute material, amorphous calcium polyphosphate. The new material is synthesized by a cement-like slif-setting reaction with calcium phosphate glass, basic materials and water. In this study, we prepared with CPG, Na2CO3 and NaOH solution. When they are mixed together, amorphous phase was precipitated. The precipitated amorphous phase consisted of polyphosphate chains condensed with Na ions released from Na2CO3 and NaOH. When the amorphous calcium polyphosphate dissolves, inorganic polyphosphates are released into the medium. The inorganic polyphosphates as the dissolution product inducted the calcification of the osteoblast cells. Therefore, in animal test, the new bone formation in rat calvarial defects treated with the new material was significantly higher than sham-surgery control group, especially in the initial stage. The amorphous calcium polyphosphate was biocompatible and bioresorbable and promoted the new bone formation
Full Text
http://www.scientific.net/KEM.396-398.209
DOI
10.4028/www.scientific.net/KEM.396-398.209
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Chul(김민철)
Lee, Byung Hyun(이병현)
Lee, Yong Keun(이용근)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104547
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