Adult ; Alleles ; Case-Control Studies ; Genome-Wide Association Study ; Genotype ; Humans ; Korea ; Male ; Obsessive-Compulsive Disorder/genetics* ; Polymorphism, Single Nucleotide* ; Receptor, Serotonin, 5-HT1B/genetics*
Keywords
5-HT1D receptor gene ; Obsessive-compulsive disorder ; Single nucleotide polymorphism
Abstract
The 5-HT1Dbeta receptor gene appears to be particularly interesting in the pathophysiology of obsessive-compulsive disorder (OCD). The 5-HT1Dbeta receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. We performed an association study of the G861C single nucleotide polymorphism (SNP) of the 5-HT1Dbeta receptor in 167 male Korean OCD subjects and in 107 controls. Individuals with the G allele had an increased chance of having OCD (OR 1.49, 95% CI 1.05-2.10). Our findings suggest an association between the G861C SNP of the 5-HT1Dbeta receptor and males with OCD. In the future, other tag SNPs that cover the entire 5-HT1Dbeta gene region as well as additional SNPs that are supposed to have meaningful functions should be investigated in both male and female OCD subjects