5 269

Cited 9 times in

Association of a 5-HT1Dbeta receptor gene polymorphism with obsessive-compulsive disorder in Korean male subjects.

DC FieldValueLanguage
dc.contributor.author강지인-
dc.contributor.author김세주-
dc.contributor.author김찬형-
dc.contributor.author남궁기-
dc.date.accessioned2015-04-24T16:56:50Z-
dc.date.available2015-04-24T16:56:50Z-
dc.date.issued2009-
dc.identifier.issn0302-282X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104470-
dc.description.abstractThe 5-HT1Dbeta receptor gene appears to be particularly interesting in the pathophysiology of obsessive-compulsive disorder (OCD). The 5-HT1Dbeta receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. We performed an association study of the G861C single nucleotide polymorphism (SNP) of the 5-HT1Dbeta receptor in 167 male Korean OCD subjects and in 107 controls. Individuals with the G allele had an increased chance of having OCD (OR 1.49, 95% CI 1.05-2.10). Our findings suggest an association between the G861C SNP of the 5-HT1Dbeta receptor and males with OCD. In the future, other tag SNPs that cover the entire 5-HT1Dbeta gene region as well as additional SNPs that are supposed to have meaningful functions should be investigated in both male and female OCD subjects-
dc.description.statementOfResponsibilityopen-
dc.format.extent96~99-
dc.relation.isPartOfNeuropsychobiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAlleles-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHObsessive-Compulsive Disorder/genetics*-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.subject.MESHReceptor, Serotonin, 5-HT1B/genetics*-
dc.titleAssociation of a 5-HT1Dbeta receptor gene polymorphism with obsessive-compulsive disorder in Korean male subjects.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorSe Joo Kim-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorChan-Hyung Kim-
dc.identifier.doi10.1159/000209861-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00084-
dc.contributor.localIdA00604-
dc.contributor.localIdA01036-
dc.contributor.localIdA01240-
dc.relation.journalcodeJ02354-
dc.identifier.pmid19325252-
dc.identifier.urlhttp://www.karger.com/Article/FullText/209861-
dc.subject.keyword5-HT1D receptor gene-
dc.subject.keywordObsessive-compulsive disorder-
dc.subject.keywordSingle nucleotide polymorphism-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNameKim, Chan Hyung-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorKim, Chan Hyung-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.citation.volume59-
dc.citation.number2-
dc.citation.startPage96-
dc.citation.endPage99-
dc.identifier.bibliographicCitationNeuropsychobiology, Vol.59(2) : 96-99, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.