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Association of a 5-HT1Dbeta receptor gene polymorphism with obsessive-compulsive disorder in Korean male subjects.

Authors
 Se Joo Kim  ;  Kee Namkoong  ;  Jee In Kang  ;  Chan-Hyung Kim 
Citation
 NEUROPSYCHOBIOLOGY, Vol.59(2) : 96-99, 2009 
Journal Title
 NEUROPSYCHOBIOLOGY 
ISSN
 0302-282X 
Issue Date
2009
MeSH
Adult ; Alleles ; Case-Control Studies ; Genome-Wide Association Study ; Genotype ; Humans ; Korea ; Male ; Obsessive-Compulsive Disorder/genetics* ; Polymorphism, Single Nucleotide* ; Receptor, Serotonin, 5-HT1B/genetics*
Keywords
5-HT1D receptor gene ; Obsessive-compulsive disorder ; Single nucleotide polymorphism
Abstract
The 5-HT1Dbeta receptor gene appears to be particularly interesting in the pathophysiology of obsessive-compulsive disorder (OCD). The 5-HT1Dbeta receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. We performed an association study of the G861C single nucleotide polymorphism (SNP) of the 5-HT1Dbeta receptor in 167 male Korean OCD subjects and in 107 controls. Individuals with the G allele had an increased chance of having OCD (OR 1.49, 95% CI 1.05-2.10). Our findings suggest an association between the G861C SNP of the 5-HT1Dbeta receptor and males with OCD. In the future, other tag SNPs that cover the entire 5-HT1Dbeta gene region as well as additional SNPs that are supposed to have meaningful functions should be investigated in both male and female OCD subjects
Full Text
http://www.karger.com/Article/FullText/209861
DOI
10.1159/000209861
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Chan Hyung(김찬형)
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104470
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