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Measurement of donor kidney functional renal volume and glomerular filtration rate to predict allograft function during the post-transplantation period.

Authors
 Kyu Ha Huh  ;  Mijin Yun  ;  Tae Sung Kim  ;  Arthur Cho  ;  Jong Doo Lee  ;  Sung Min Myoung  ;  Yu Seun Kim  ;  Myoung Soo Kim 
Citation
 NEPHRON, Vol.113(4) : 262-269, 2009 
Journal Title
 NEPHRON 
ISSN
 1660-8151 
Issue Date
2009
MeSH
Adult ; Female ; Glomerular Filtration Rate* ; Graft Rejection/diagnosis* ; Graft Rejection/etiology* ; Humans ; Kidney/diagnostic imaging* ; Kidney Transplantation/adverse effects* ; Kidney Transplantation/diagnostic imaging* ; Male ; Middle Aged ; Organ Size ; Postoperative Period ; Radioisotope Renography/methods* ; Reproducibility of Results ; Sensitivity and Specificity ; Treatment Outcome ; Young Adult
Keywords
Allograft function ; Functional renal volume ; Glomerular filtration rate ; Kidney transplantation ; Kidney weight
Abstract
BACKGROUND: We measured donor kidney weight (D-KW), functional renal volume (D-FRV), and single-kidney glomerular filtration rate (D-SKGFR), and then evaluated the impact of the indices to recipient body weight (R-BW) on graft function. METHODS: This study included 44 recipients of live donor transplants without delayed graft function or acute rejection within 2 years of transplantation. RESULTS: There was a statistically significant difference in serum creatinine between recipients with a D-KW/R-BW ratio of <or=4.25, D-FRV/R-BW ratio of <or=5.14, or D-SKGFR/R-BW ratio of <or=1.06 and recipients with a D-KW/R-BW ratio of >4.25, D-FRV/R-BW ratio of >5.14, or D-SKGFR/R-BW ratio of >1.06, respectively. D-KW/R-BW, D-FRV/R-BW, and D-SKGFR/R-BW strongly correlated with serum creatinine at 1 year and 2 years post-transplantation. In multivariate analysis, D-FRV and donor age were statistically significant risk factors which influenced serum creatinine at 1 year and 2 years post-transplantation. CONCLUSION: D-FRV/R-BW and donor age have significant impact on graft function. D-FRV/R-BW can be measured ahead of surgery. Therefore, measuring the D-FRV is useful to select a more optimal donor kidney among otherwise similar candidates during preoperative evaluation to improve posttransplant graft function.
Full Text
http://www.karger.com/Article/FullText/235251
DOI
10.1159/000235251
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Gastroenterology (소화기병연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Kim, Tae Sung(김태성)
Myung, Sung Min(명성민)
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Jong Doo(이종두)
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104207
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