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Patterns of late gadolinium enhancement are associated with ventricular stiffness in patients with advanced non-ischaemic dilated cardiomyopathy.

 Eui-Young Choi  ;  Byoung Wook Choi  ;  Sung-Ai Kim  ;  Sang Jae Rhee  ;  Chi Young Shim  ;  Young Jin Kim  ;  Seok-Min Kang  ;  Jong-Won Ha  ;  Namsik Chung 
 EUROPEAN JOURNAL OF HEART FAILURE, Vol.11(6) : 573-580, 2009 
Journal Title
Issue Date
Cardiomyopathy, Dilated/diagnosis* ; Cardiomyopathy, Dilated/physiopathology ; Contrast Media/adverse effects* ; Echocardiography, Doppler ; Elasticity/drug effects ; Female ; Follow-Up Studies ; Gadolinium DTPA/adverse effects* ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology* ; Humans ; Magnetic Resonance Angiography/adverse effects ; Magnetic Resonance Angiography/methods* ; Male ; Middle Aged ; Myocardial Contraction/drug effects* ; Prospective Studies ; Risk Factors
dilated cardiomyopathy ; ventricular elastance ; magnetic resonance imaging
AIMS: Despite the prognostic importance of ventricular filling and ventricular-arterial interaction in patients with advanced systolic heart failure, the structural determinants of these parameters have not been fully studied. We aimed to investigate whether patterns of late gadolinium enhancement (LGE) on cardiac magnetic resonance affect ventricular elastic properties or performance in patients with non-ischaemic dilated cardiomyopathy (DCM). METHODS AND RESULTS: Patients (n = 49) with markedly reduced systolic function (left ventricular (LV) ejection fraction <35%) due to longstanding non-ischaemic DCM underwent contrast-enhanced cardiac magnetic resonance after comprehensive echo-Doppler evaluations. The single beat-derived end-diastolic elastance, end-systolic elastance, arterial elastance, and dyssynchrony indices were measured by echo. On the basis of LGE patterns, patients could be divided into three groups: non-LGE (n = 18), non-midwall LGE (n = 13), and midwall LGE (n = 18). The midwall LGE group had lower LV systolic longitudinal velocity (4.6 +/- 1.7 for non-LGE vs. 4.3 +/- 1.2 for non-midwall LGE vs. 3.5 +/- 1.0 cm/s for midwall LGE, P = 0.025), higher end-diastolic elastance index (0.41 +/- 0.21 vs. 0.46 +/- 0.31 vs. 0.85 +/- 0.51 respectively, P = 0.008), and a more impaired ventriculoarterial coupling index (3.14 +/- 1.53 vs. 2.88 +/- 1.94 vs. 5.52 +/- 3.18, P = 0.006) than other subgroups. CONCLUSION: Patients with midwall LGE had a higher ventricular stiffness index and more impaired ventriculoarterial coupling when compared with other non-ischaemic DCM patients.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Sung Ai(김성애)
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Lee, Sang Jae(이상재)
Chung, Nam Sik(정남식)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
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