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Considerations for implantation site of VX2 carcinoma into rabbit liver.

Authors
 Kwang-Hun Lee  ;  Eleni Liapi  ;  Manon Buijs  ;  Josephina Vossen  ;  Kelvin Hong  ;  Christos Georgiades  ;  Jean-Francois H. Geschwind 
Citation
 JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, Vol.20(1) : 113-117, 2009 
Journal Title
 JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY 
ISSN
 1051-0443 
Issue Date
2009
MeSH
Angiography, Digital Subtraction ; Animals ; Carcinoma/blood supply* ; Carcinoma/diagnostic imaging ; Carcinoma/pathology ; Carcinoma/therapy ; Chemoembolization, Therapeutic* ; Hepatic Artery*/diagnostic imaging ; Injections ; Liver Neoplasms, Experimental/blood supply* ; Liver Neoplasms, Experimental/diagnostic imaging ; Liver Neoplasms, Experimental/pathology ; Liver Neoplasms, Experimental/therapy ; Male ; Neoplasm Transplantation ; Neovascularization, Pathologic/diagnostic imaging ; Rabbits
Abstract
PURPOSE: To assess whether the implantation site of VX2 carcinoma into rabbit liver affects successful vessel selection for transcatheter arterial interventions. MATERIALS AND METHODS: Twenty-four New Zealand White rabbits were randomly assigned to two groups. All implantations were performed by open laparotomy with minced tumor cells inserted into a 16-gauge Angiocath needle. Group I rabbits (n = 12) had tumor implanted into the left medial lobe of the liver and group II rabbits (n = 12) had tumor implanted into the left lateral lobe. Two weeks after implantation, selective angiography was performed for subsequent chemoembolization, which was part of a different study. Tested variables included maximum tumor diameter, tumor feeding artery size, and tumor vascularity. RESULTS: Successful tumor growth was achieved in all rabbits. Selective angiography was possible in 33.3% of rabbits in group I and 66.6% of rabbits in group II (P < .05). Tumor size and vascularity were similar between groups. Mean lengths of tumor feeder arteries from the bifurcation of the left hepatic artery were 4.1 mm +/- 1.2 in group I (left medial lobe) and 10.8 mm +/- 3.0 in group II (left lateral lobe; P < .05). The angulation of the left medial lobar artery (group I) off the left hepatic artery was acute in eight of 12 rabbits (66.6%), but only four of 12 rabbits in group II (33.3%) showed acute angulation of the left lateral lobar artery off the left hepatic artery (P < .05). Mean angiography time was significantly shorter in group II. CONCLUSIONS: For selective hepatic arterial interventions, the left lateral lobe of the liver may be favorable as an implantation site for VX2 tumors in rabbits.
Files in This Item:
T200901439.pdf Download
DOI
10.1016/j.jvir.2008.09.033
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hun(이광훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103943
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