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A concise synthesis of licochalcone E and its regio-isomer, licochalcone F.

Authors
 Younghwa NA  ;  Jeong-Heon CHA  ;  Ho-Geun YOON  ;  Youngjoo KWON 
Citation
 CHEMICAL & PHARMACEUTICAL BULLETIN, Vol.57(6) : 607-609, 2009 
Journal Title
 CHEMICAL & PHARMACEUTICAL BULLETIN 
ISSN
 0009-2363 
Issue Date
2009
MeSH
Chalcones/chemical synthesis* ; Chalcones/pharmacology ; Cyclin D1/antagonists & inhibitors ; Glycyrrhiza/chemistry ; Indicators and Reagents ; Isomerism ; Magnetic Resonance Spectroscopy ; NF-kappa B/antagonists & inhibitors ; Solvents ; Spectrometry, Mass, Electrospray Ionization
Abstract
Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regio-isomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis.
Files in This Item:
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DOI
10.1248/cpb.57.607
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Cha, Jung Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103908
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