Cited 18 times in
A concise synthesis of licochalcone E and its regio-isomer, licochalcone F.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 차정헌 | - |
dc.date.accessioned | 2015-04-24T16:38:52Z | - |
dc.date.available | 2015-04-24T16:38:52Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103908 | - |
dc.description.abstract | Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regio-isomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 607~609 | - |
dc.relation.isPartOf | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Chalcones/chemical synthesis* | - |
dc.subject.MESH | Chalcones/pharmacology | - |
dc.subject.MESH | Cyclin D1/antagonists & inhibitors | - |
dc.subject.MESH | Glycyrrhiza/chemistry | - |
dc.subject.MESH | Indicators and Reagents | - |
dc.subject.MESH | Isomerism | - |
dc.subject.MESH | Magnetic Resonance Spectroscopy | - |
dc.subject.MESH | NF-kappa B/antagonists & inhibitors | - |
dc.subject.MESH | Solvents | - |
dc.subject.MESH | Spectrometry, Mass, Electrospray Ionization | - |
dc.title | A concise synthesis of licochalcone E and its regio-isomer, licochalcone F. | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Younghwa NA | - |
dc.contributor.googleauthor | Jeong-Heon CHA | - |
dc.contributor.googleauthor | Ho-Geun YOON | - |
dc.contributor.googleauthor | Youngjoo KWON | - |
dc.identifier.doi | 10.1248/cpb.57.607 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A04007 | - |
dc.relation.journalcode | J00509 | - |
dc.identifier.eissn | 1347-5223 | - |
dc.identifier.pmid | 19483343 | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.alternativeName | Cha, Jung Heon | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Cha, Jung Heon | - |
dc.citation.volume | 57 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 607 | - |
dc.citation.endPage | 609 | - |
dc.identifier.bibliographicCitation | CHEMICAL & PHARMACEUTICAL BULLETIN, Vol.57(6) : 607-609, 2009 | - |
dc.identifier.rimsid | 37875 | - |
dc.type.rims | ART | - |
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