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How to combine ultrasound and cytological information in decision making about thyroid nodules

Authors
 Jin Young Kwak  ;  Eun-Kyung Kim  ;  Hye Jung Kim  ;  Min Jung Kim  ;  Eun Ju Son  ;  Hee Jung Moon 
Citation
 EUROPEAN RADIOLOGY, Vol.19(8) : 1923-1931, 2009 
Journal Title
 EUROPEAN RADIOLOGY 
ISSN
 0938-7994 
Issue Date
2009
MeSH
Adolescent ; Adult ; Aged ; Biopsy, Fine-Needle/statistics & numerical data* ; False Negative Reactions ; Female ; Humans ; Image Enhancement/methods* ; Image Interpretation, Computer-Assisted/methods* ; Korea/epidemiology ; Male ; Middle Aged ; Prevalence ; Reproducibility of Results ; Risk Assessment/methods ; Risk Factors ; Sensitivity and Specificity ; Subtraction Technique/statistics & numerical data ; Thyroid Nodule/diagnosis* ; Thyroid Nodule/epidemiology* ; Ultrasonography/statistics & numerical data* ; Young Adult
Keywords
Thyroid cancer ; Ultrasound ; Fine-needle aspiration
Abstract
The purpose of this study was to evaluate the role of sonographic-cytological correlation in determining which nodules should be reaspirated to reduce the false-negative rate of fine-needle aspiration biopsy (FNAB). A retrospective cohort study was performed on a database of 568 patients with 672 focal thyroid nodules. An independent two-sample t-test was used to compare the risk of malignancy according to clinical factors. We evaluated the risk stratification of malignancy according to US groupings and cytological results. Additionally, we calculated the false-negative rate of FNAB and investigated the cytological results of repeat aspiration. The malignancy rate (92.2-98.5%) was high in thyroid nodules designated "malignant" or "suspicious for papillary carcinoma" on FNAB, regardless of US features. In contrast, when focal thyroid nodules had "benign" readings on FNAB, the malignancy rate was lower for the "probably benign" US features (2.9%) than for the suspicious nodules (56.6%). The false-negative rate of FNAB was 5.8%. Repeat aspiration revealed "suspicious for malignancy" or "malignancy" results in 15 (93.8%) of 16 thyroid cancers with "benign" results on initial aspirate. This study demonstrated repeat FNAB should be performed on focal thyroid nodules with suspicious US features even when initial FNAB results are benign.
Full Text
http://link.springer.com/article/10.1007%2Fs00330-009-1369-7
DOI
10.1007/s00330-009-1369-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103882
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