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Bisphosphonates induced osteonecrosis of the jaw의 기전, 예방, 위험 평가 및 치료 방법

Other Titles
 Mechanism, prevention, risk assessment and treatment in bisphosphonates induced osteonecrosis of the jaw 
Authors
 박정철  ;  정의원  ;  김창성  ;  조규성  ;  채중규  ;  김종관  ;  최성호 
Citation
 Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.39(1) : 1-8, 2009 
Journal Title
 Journal of Korean Academy of Periodontology (대한치주과학회지) 
ISSN
 2093-2278 
Issue Date
2009
Keywords
Bisphosphonates ; osteonecrosis of the jaw ; osteoporosis
Abstract
PURPOSE: Bisphophonates are drugs used to suppress osteoclastic activity and to treat osteoporosis, Paget's disease of bone and bone metastasis. The purpose of this report is to review the literatures on bisphopsphonates use that could affect bone healing and cause osteonecrosis of the jaws. MATERIALS AND METHODS: Medline research was carried out to find relevant articles on bisphophonates and osteonecrosis of the jaw. RESULTS: Oral administration of bisphopsphonates is reported to decrease the risk of adverse bone outcomes. On the contrary, IV bisphopsphonates is known to significantly increase the risk. Prevention of the osteonecrosis of the jaw is primary concern before usage. If the adverse bone reaction takes place, proper management and treatments are required to alleviate pain of patients and prevent further progression of necrosis. CONCLUSION: Case reports of bisphosphonates induced osteonecrosis of the jaw are increasing. Dentists and physicians should be aware of the higher frequency of osteonecrosis of the jaw in patients receiving IV bisphopsphonates and be prepared to prevent and cope with adverse bone reaction.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Chai, Jung Kyu(채중규)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103828
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