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백서두개골 결손부에서 Escherichia coli 발현 시스템으로 생산된 rhBMP-2의 골형성 효과

Other Titles
 Effect of rhBMP-2 produced by Escherichia coli expression system on bone formation in rat calvarial defects 
 권석훈  ;  임현창  ;  최경희  ;  김민수  ;  이지현  ;  정의원  ;  윤정호  ;  김창성  ;  최성호  ;  조규성 
 Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.39(1) : 77-86, 2009 
Journal Title
Journal of Korean Academy of Periodontology(대한치주과학회지)
Issue Date
bone morphogenetic protein-2 ; E.coli expression system ; Absorbable collagen sponge ; rat calvarial defect
PURPOSE: Recombinant human bone morphogenetic protein-2(rhBMP-2) has been evaluated as potential candidates for periodontal and bone regenerative therapy. In spite of good prospects in BMP applications, there is economically unavailable for clinical use in dental area. The purpose of this study was to evaluate the osteogenic effect of rhBMP-2 produced by E.coli expression system. MATERIALS AND METHODS: Eight-mm critical-size calvarial defects were created in 48 male Sprague-Dawley rats. The animals were divided into 6 groups of 8 animals each. Each group received one of the following: Negative control(sham-surgery control), positive control(absorbable collagen sponge(ACS) alone) and experimental(ACS loaded with rhBMP-2). Defects were evaluated by histologic and histometric parameters following 2- and 8-week healing intervals. RESULTS: The experimental group showed significant defect closure at 2 and 8weeks than the sham surgery and positive control groups. Moreover, the experimental group showed significantly greater new bone and augmented area than the other groups at both 2 and 8weeks. CONCLUSION: rhBMP-2 produced by E.coli expression system may be effective for bone regeneration
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Yun, Jeong Ho(윤정호)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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