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Concomitant isochromosome 17q and trisomy 14 in a patient with myelodysplastic syndrome in leukemic transformation

Authors
 Tae Sung Park  ;  Jaewoo Song  ;  Jong-Han Lee  ;  Jin Seok Kim  ;  Woo Ick Yang  ;  Jong Rak Choi 
Citation
 ANNALS OF CLINICAL AND LABORATORY SCIENCE, Vol.39(2) : 176-181, 2009 
Journal Title
 ANNALS OF CLINICAL AND LABORATORY SCIENCE 
ISSN
 0091-7370 
Issue Date
2009
MeSH
Aged ; Cell Transformation, Neoplastic/genetics* ; Chromosome Mapping ; Chromosomes, Human, Pair 14* ; Chromosomes, Human, Pair 17 ; Fatal Outcome ; Humans ; Isochromosomes/genetics* ; Leukemia/genetics* ; Male ; Myelodysplastic Syndromes/genetics* ; Trisomy*
Keywords
isochromosome 17q ; trisomy 1 ; 4 myelodysplastic syndrome ; leukemic transformation
Abstract
We describe a novel case of simultaneous karyotypic abnormalities of isochromosome 17q and trisomy 14 in a patient with myelodysplastic syndrome (MDS) in leukemic transformation. A 66-yr-old Korean man was admitted to Severance Hospital for evaluation of pancytopenia. On the basis of bone marrow studies at 3 different stages, he was diagnosed with MDS in leukemic transformation. Chromosome karyotyping repeatedly showed the same main clonal abnormalities, including isochromosome 17q and trisomy 14. Isochromosome 17q and trisomy 14 have each been reported as rare, nonrandom recurrent chromosomal abnormalities in patients with MDS showing a poor prognosis. To our knowledge, this is the first report of concurrent i(17)(q10) and trisomy 14 in a patient with MDS in leukemic transformation
Full Text
http://www.annclinlabsci.org/content/39/2/176.long
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Jong Han(이종한)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103788
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