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Morphogenesis and biological significance of spindle cell transformation in a spindle cell carcinoma

Authors
 Eun Jung Kim  ;  Zhong Min Che  ;  Young Jin Park  ;  Young Sun Hwang  ;  Ki Yeol Kim  ;  Da Woon Jung  ;  Nam Kyung Jeon  ;  Young Wook Choi  ;  Eun Ju Lee  ;  Jin Kim 
Citation
 Cancer Letters Vol.275(1):61-71 
Journal Title
 Cancer Letters 
ISSN
 0304-3835 
Issue Date
2009
Abstract
Our study investigated the histogenesis and biological significance of spindle cell carcinoma (SpCC) by comparing with moderately-well-differentiated squamous cell carcinoma (SCC) cell lines. Snail mRNA expression was readily detectable in the SpCC cell line, while E-cadherin was undetectable. SpCC cells showed lower proliferative and invasive activities than two other SCC cell lines. Culturing under air-liquid interface conditions promoted squamous cell differentiation, whereas fibroblastic differentiation after submerged culture with collagen, suggesting that the microenvironment may be a regulating factor of spindle cell differentiation as well as Snail expression and spindle cell change may not always entail the invasive behavior
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383508008082
DOI
10.1016/j.canlet.2008.10.004
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실)
Yonsei Authors
김기열(Kim, Ki Yeol) ORCID logo https://orcid.org/0000-0001-5357-1067
김은정(Kim, Eun Jung)
김진(Kim, Jin)
박영진(Park, Young Jin)
정다운(Jung, Da Woon)
차충민(Che, Zhong Min)
황영선(Hwang, Young Sun)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103590
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