1 351

Cited 8 times in

Morphogenesis and biological significance of spindle cell transformation in a spindle cell carcinoma

Authors
 Eun Jung Kim  ;  Zhong Min Che  ;  Young Jin Park  ;  Young Sun Hwang  ;  Ki Yeol Kim  ;  Da Woon Jung  ;  Nam Kyung Jeon  ;  Young Wook Choi  ;  Eun Ju Lee  ;  Jin Kim 
Citation
 CANCER LETTERS, Vol.275(1) : 61-71, 2009 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
2009
MeSH
Adult ; Animals ; Cadherins/metabolism ; Carcinoma/metabolism* ; Carcinoma/pathology* ; Carcinoma, Squamous Cell/metabolism* ; Carcinoma, Squamous Cell/pathology* ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic* ; Epithelium/metabolism ; Fibroblasts/metabolism ; Humans ; Male ; Mesoderm/metabolism ; Mice ; Mice, Inbred BALB C ; Snail Family Transcription Factors ; Transcription Factors/metabolism
Keywords
Spindle cell carcinoma ; Invasiveness ; Spindle cell transformation ; Microenvironment ; Epithelial mesenchymal transition
Abstract
Our study investigated the histogenesis and biological significance of spindle cell carcinoma (SpCC) by comparing with moderately-well-differentiated squamous cell carcinoma (SCC) cell lines. Snail mRNA expression was readily detectable in the SpCC cell line, while E-cadherin was undetectable. SpCC cells showed lower proliferative and invasive activities than two other SCC cell lines. Culturing under air-liquid interface conditions promoted squamous cell differentiation, whereas fibroblastic differentiation after submerged culture with collagen, suggesting that the microenvironment may be a regulating factor of spindle cell differentiation as well as Snail expression and spindle cell change may not always entail the invasive behavior
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383508008082
DOI
10.1016/j.canlet.2008.10.004
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Kim, Eun-Jung(김은정) ORCID logo https://orcid.org/0000-0002-9515-7590
Kim, Jin(김진)
Park, Young Jin(박영진)
Jung, Da Woon(정다운)
Che, Zhong Min(차충민)
Hwang, Young Sun(황영선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103590
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse