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Morphogenesis and biological significance of spindle cell transformation in a spindle cell carcinoma

DC Field Value Language
dc.contributor.author김기열-
dc.contributor.author김은정-
dc.contributor.author김진-
dc.contributor.author박영진-
dc.contributor.author정다운-
dc.contributor.author차충민-
dc.contributor.author황영선-
dc.contributor.authorKim, Ki Yeol-
dc.contributor.authorJung, Da Woon-
dc.contributor.authorChe, Zhong Min-
dc.contributor.authorHwang, Young Sun-
dc.contributor.authorKim, Jin-
dc.contributor.authorPark, Young Jin-
dc.contributor.authorKim, Eun Jung-
dc.date.accessioned2015-04-24T16:28:48Z-
dc.date.available2015-04-24T16:28:48Z-
dc.date.issued2009-
dc.identifier.issn0304-3835-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103590-
dc.description.abstractOur study investigated the histogenesis and biological significance of spindle cell carcinoma (SpCC) by comparing with moderately-well-differentiated squamous cell carcinoma (SCC) cell lines. Snail mRNA expression was readily detectable in the SpCC cell line, while E-cadherin was undetectable. SpCC cells showed lower proliferative and invasive activities than two other SCC cell lines. Culturing under air-liquid interface conditions promoted squamous cell differentiation, whereas fibroblastic differentiation after submerged culture with collagen, suggesting that the microenvironment may be a regulating factor of spindle cell differentiation as well as Snail expression and spindle cell change may not always entail the invasive behavior-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCANCER LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnimals-
dc.subject.MESHCadherins/metabolism-
dc.subject.MESHCarcinoma/metabolism*-
dc.subject.MESHCarcinoma/pathology*-
dc.subject.MESHCarcinoma, Squamous Cell/metabolism*-
dc.subject.MESHCarcinoma, Squamous Cell/pathology*-
dc.subject.MESHCell Differentiation-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCell Transformation, Neoplastic*-
dc.subject.MESHEpithelium/metabolism-
dc.subject.MESHFibroblasts/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMesoderm/metabolism-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHSnail Family Transcription Factors-
dc.subject.MESHTranscription Factors/metabolism-
dc.titleMorphogenesis and biological significance of spindle cell transformation in a spindle cell carcinoma-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Cancer Research Institute (구강종양연구소)-
dc.contributor.googleauthorEun Jung Kim-
dc.contributor.googleauthorZhong Min Che-
dc.contributor.googleauthorYoung Jin Park-
dc.contributor.googleauthorYoung Sun Hwang-
dc.contributor.googleauthorKi Yeol Kim-
dc.contributor.googleauthorDa Woon Jung-
dc.contributor.googleauthorNam Kyung Jeon-
dc.contributor.googleauthorYoung Wook Choi-
dc.contributor.googleauthorEun Ju Lee-
dc.contributor.googleauthorJin Kim-
dc.identifier.doi10.1016/j.canlet.2008.10.004-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01571-1-
dc.contributor.localIdA04010-
dc.contributor.localIdA00337-
dc.contributor.localIdA03588-
dc.contributor.localIdA04472-
dc.contributor.localIdA01009-
dc.contributor.localIdA00814-
dc.relation.journalcodeJ00448-
dc.identifier.eissn1872-7980-
dc.identifier.pmid19006647-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304383508008082-
dc.subject.keywordSpindle cell carcinoma-
dc.subject.keywordInvasiveness-
dc.subject.keywordSpindle cell transformation-
dc.subject.keywordMicroenvironment-
dc.subject.keywordEpithelial mesenchymal transition-
dc.contributor.alternativeNameKim, Ki Yeol-
dc.contributor.alternativeNameKim, Eun Jung-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.alternativeNamePark, Young Jin-
dc.contributor.alternativeNameJung, Da Woon-
dc.contributor.alternativeNameChe, Zhong Min-
dc.contributor.alternativeNameHwang, Young Sun-
dc.contributor.affiliatedAuthorPark, Young Jin-
dc.contributor.affiliatedAuthorChe, Zhong Min-
dc.contributor.affiliatedAuthorKim, Ki Yeol-
dc.contributor.affiliatedAuthorJung, Da Woon-
dc.contributor.affiliatedAuthorHwang, Young Sun-
dc.contributor.affiliatedAuthorKim, Jin-
dc.contributor.affiliatedAuthorKim, Eun Jung-
dc.citation.volume275-
dc.citation.number1-
dc.citation.startPage61-
dc.citation.endPage71-
dc.identifier.bibliographicCitationCANCER LETTERS, Vol.275(1) : 61-71, 2009-
dc.identifier.rimsid37939-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
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