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Can microvessel invasion of hepatocellular carcinoma be predicted by pre-operative MRI?

 Honsoul Kim  ;  Mi-Suk Park  ;  Jin Young Choi  ;  Young Nyun Park  ;  Myeong-Jin Kim  ;  Kyung Sik Kim  ;  Jin Sub Choi  ;  Kwang-Hyub Han  ;  EunJu Kim  ;  Ki Whang Kim 
 EUROPEAN RADIOLOGY, Vol.19(7) : 1744-1751, 2009 
Journal Title
Issue Date
Adult ; Aged ; Carcinoma, Hepatocellular/pathology* ; Carcinoma, Hepatocellular/surgery ; Female ; Humans ; Liver Neoplasms/pathology* ; Liver Neoplasms/surgery ; Magnetic Resonance Imaging/methods* ; Male ; Microvessels/pathology* ; Middle Aged ; Neoplasm Invasiveness ; Neovascularization, Pathologic/pathology* ; Neovascularization, Pathologic/surgery ; Preoperative Care/methods ; Prognosis ; Sensitivity and Specificity
Hepatocellular carcinoma ; Microvessel tumor invasion ; Peritumoral enhancement ; MRI
Microvessel invasion is a major prognostic factor in hepatocellular carcinoma (HCC) that influences the suitability of surgery, but rarely can be evaluated preoperatively. This study was performed to identify preoperative MRI findings that reflect histopathological microvessel invasion in hepatocellular carcinoma. Gadobenate dimeglumine-enhanced four-arterial phase dynamic study and hepatobiliary phase images of preoperative MRI of 70 HCC lesions were retrospectively reviewed. Tumor size (cm), peritumoral enhancement, tumor margins, and radiological capsule were analyzed as radiological parameters reflecting microvessel invasion and were compared with histopathological references. The chi-square test and the independent t-test were used for univariate analysis, and a logistic regression analysis was performed for multivariate analysis. In univariate analysis, tumor size (p = 0.030), peritumoral enhancement (p < 0.001), and tumor margins (p = 0.007) were associated with microvessel tumor invasion. However, in multivariate analysis irregular circumferential peritumoral enhancement only showed statistical significance (odds ratio 13.0), suggesting a high probability of microvessel invasion of HCC. Irregular circumferential peritumoral enhancement on contrast-enhanced multi-arterial phase dynamic MRI could be a preoperative surrogate marker for microvessel tumor invasion.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Choi, Jin Sub(최진섭)
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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