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Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development

Authors
 Jae-Young Kim  ;  Min-Jung Lee  ;  Kyoung-Won Cho  ;  Jong-Min Lee  ;  Yeun-Jung Kim  ;  Ji-Youn Kim  ;  Hye-In Jung  ;  Je-Yoel Cho  ;  Sung-Won Cho  ;  Han-Sung Jung 
Citation
 DEVELOPMENTAL BIOLOGY, Vol.325(1) : 273-280, 2009 
Journal Title
 DEVELOPMENTAL BIOLOGY 
ISSN
 0012-1606 
Issue Date
2009
MeSH
Amides/pharmacology ; Animals ; Cell Movement/drug effects ; Epithelium/drug effects ; Epithelium/embryology* ; Epithelium/enzymology* ; Epithelium/metabolism ; Gene Expression Regulation, Developmental/drug effects ; Hedgehog Proteins/metabolism* ; Mice ; Mice, Inbred ICR ; Models, Biological ; Morphogenesis*/drug effects ; Organ Culture Techniques ; Pyridines/pharmacology ; Tongue/cytology ; Tongue/embryology* ; Tongue/enzymology* ; rho-Associated Kinases/antagonists & inhibitors ; rho-Associated Kinases/metabolism*
Keywords
Circumvallate papilla ; ROCK1 ; Wnt11 ; Shh ; Cytoskeleton ; Proliferation
Abstract
In rodents, a circumvallate papilla (CVP) develops with dynamic changes in epithelial morphogenesis during early tongue development. Molecular and cellular studies of CVP development revealed that there would be two different mechanisms in the apex and the trench wall forming regions with specific expression patterns of Wnt11 and Shh. Molecular interactions were examined using in vitro organ culture with over-expression of Shh, important signalling molecules and various inhibitors revealed that there are two significant different mechanisms in CVP formation by Wnt11 and Shh expressions. Wnt, a well known key molecule to initiate taste papillae, would govern Rho activation and cytoskeleton formation in the apex epithelium of CVP. In contrast, Shh regulates the cell proliferation to differentiate taste buds and to invaginate the epithelium for development of von Ebner's gland (VEG). Based on these results, we suggest that these different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development.
Full Text
http://www.sciencedirect.com/science/article/pii/S0012160608013006
DOI
10.1016/j.ydbio.2008.10.034
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yeun Jung(김연정)
Kim, Ji Youn(김지연)
Lee, Min Jung(이민정)
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Kyoung Won(조경원)
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103451
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