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Elevated white blood cell count is associated with arterial stiffness

Authors
 Yong-Jae Lee  ;  Ji-Won Lee  ;  Jong-Koo Kim  ;  Jung-Hyun Lee  ;  Jin-Hyun Kim  ;  Kil-Young Kwon  ;  Hye-Ree Lee  ;  Duk-Chul Lee  ;  Jae-Yong Shim 
Citation
 NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, Vol.19(1) : 3-7, 2009 
Journal Title
 NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 
ISSN
 0939-4753 
Issue Date
2009
MeSH
Adult ; Aged ; Ankle/blood supply ; Arteries/physiopathology* ; Biomechanical Phenomena ; Blood Pressure ; Brachial Artery ; Cardiovascular Diseases/physiopathology ; Electrocardiography ; Female ; Humans ; Leukocyte Count* ; Male ; Middle Aged ; Plethysmography ; Regression Analysis
Keywords
White blood cell ; Cardiovascular disease ; Arterial stiffness ; Pulse wave velocity
Abstract
BACKGROUND AND AIMS: White blood cell (WBC) count, a usual marker of systemic inflammation, is known to be associated with atherosclerotic cardiovascular disease. The aim of the present study was to determine the association of WBC count with arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). METHODS AND RESULTS: We examined the association between WBC count and baPWV in 788 Korean adults (375 men, 413 women) in a health examination program. The odds ratios for a high baPWV were calculated using multivariate logistic regression analysis after adjusting for confounding variables across WBC count quartiles (Q1: <or=5190, Q2: 5200-6080, Q3: 6090-7310, and Q4: >or=7320 cells/mm(3)). A high baPWV was defined as more than 1440 cm/s (>75th percentile). Age-adjusted baPWV mean values gradually increased with WBC quartiles (Q1=1294, Q2=1322, Q3=1347, and Q4=1367 cm/s). The odds ratios (95% CI) for a high baPWV in each WBC count quartile were 1.00, 1.34 (0.61-3.00), 2.20 (0.96-5.06), and 2.69 (1.15-6.47) after adjusting for age, sex, cigarette smoking, alcohol intake, regular exercise, body mass index (BMI), mean arterial blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, gamma-glutamyltransferase (GGT), and uric acid. CONCLUSION: These findings indicate that elevated WBC count is associated with arterial stiffness. Accordingly, early detection of an elevated WBC count is important for arterial function and the assessment of cardiovascular risk
Full Text
http://www.sciencedirect.com/science/article/pii/S0939475308000537
DOI
10.1016/j.numecd.2008.02.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Kil Young(권길영)
Kim, Jong Koo(김종구)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Jung Hyun(이정현)
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
Lee, Hye Ree(이혜리)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103450
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