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Elevated cardiac troponin T predicts cardiovascular events in asymptomatic continuous ambulatory peritoneal dialysis patients without a history of cardiovascular disease

Authors
 Seung Hyeok Han  ;  Hoon Young Choi  ;  Dong Ki Kim  ;  Sung Jin Moon  ;  Jung Eun Lee  ;  Tae Hyun Yoo  ;  Beom Seok Kim  ;  Shin-Wook Kang  ;  Kyu Hun Choi  ;  Ho Yung Lee  ;  Dae-Suk Han 
Citation
 AMERICAN JOURNAL OF NEPHROLOGY, Vol.29(2) : 129-135, 2009 
Journal Title
AMERICAN JOURNAL OF NEPHROLOGY
ISSN
 0250-8095 
Issue Date
2009
MeSH
Adult ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Cardiovascular Diseases/blood* ; Cardiovascular Diseases/mortality* ; Female ; Follow-Up Studies ; Humans ; Interleukin-6/blood ; Kaplan-Meier Estimate ; Kidney Failure, Chronic/blood* ; Kidney Failure, Chronic/mortality* ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Peritoneal Dialysis, Continuous Ambulatory/statistics & numerical data* ; Predictive Value of Tests ; Prevalence ; Prospective Studies ; Risk Factors ; Troponin T/blood*
Keywords
Cardiac troponin T ; Peritoneal dialysis ; Cardiovascular events
Abstract
BACKGROUND: Recent studies revealed that elevated cardiac troponin T (cTnT) could predict all-cause mortality and cardiovascular diseases in end-stage renal disease patients. This study aimed to evaluate cTnT as a prognostic value in asymptomatic continuous ambulatory peritoneal dialysis patients.

METHODS: This is a prospective observational study with 107 prevalent peritoneal dialysis patients. cTnT, high-sensitive C-reactive protein (hsCRP) and IL-6 were measured at baseline. Based on cTnT level, patients were classified as higher cTnT group (HT, n = 21, cTnT > or =0.1 ng/ml) and lower cTnT group (LT, n = 86, cTnT <0.1 ng/ml), and were followed for 3 years. Primary endpoint was cardiovascular events.

RESULTS: The HT group had a significantly higher level of log hsCRP and log IL-6 than the LT group (p < 0.05). Kaplan-Meier survival demonstrated worse cardiovascular event-free survival for the HT group. Multivariate analysis adjusted for age, cTnT, IL-6 and hsCRP level revealed that age (per 1-year increase, HR 1.07, p < 0.05), elevated cTnT (vs. <0.1 ng/ml, HR 5.89, p < 0.05) and hsCRP (vs. <3.0 mg/l, HR 4.15, p < 0.05) were identified as significant determinants of cardiovascular events.

CONCLUSION: This study suggests that cTnT may be an aid in risk stratification of continuous ambulatory peritoneal dialysis patients
Full Text
http://www.karger.com/Article/FullText/151634
DOI
10.1159/000151634
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Dong Ki(김동기)
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Moon, Sung Jin(문성진)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Lee, Ho Yung(이호영)
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
Han, Dae Suk(한대석)
Han, Seung Jin(한승진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103413
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