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Reduced visual P300 amplitudes in individuals at ultra-high risk for psychosis and first-episode schizophrenia

Authors
 Su Young Lee  ;  Kee Namkoong  ;  Hye Hyun Cho  ;  Dong-Ho Song  ;  Suk Kyoon An 
Citation
 NEUROSCIENCE LETTERS, Vol.486(3) : 156-160, 2010 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2010
MeSH
Adolescent ; Adult ; Brain Mapping/methods ; Disease Susceptibility ; Early Diagnosis ; Electroencephalography/methods ; Event-Related Potentials, P300/physiology* ; Evoked Potentials, Visual/physiology* ; Female ; Humans ; Male ; Neuropsychological Tests/standards ; Photic Stimulation/methods ; Psychotic Disorders/diagnosis* ; Psychotic Disorders/physiopathology* ; Risk Assessment/methods ; Risk Factors ; Schizophrenia/diagnosis* ; Schizophrenia/physiopathology* ; Visual Cortex/physiopathology* ; Visual Pathways/physiopathology ; Young Adult
Keywords
Ultra-high risk for psychosisFirst-episode schizophreniaP300Event-related potentialsNegative symptomsVisuospatial oddball task
Abstract
The purpose of this study was to investigate whether individuals at ultra-high risk (UHR) for psychosis and patients experiencing first-episode schizophrenia had impairments in visual information processing as indexed by the visual P300 event-related potential. Sixteen UHR individuals, 21 first-episode schizophrenia patients, and 16 healthy controls were included. Participants were asked to perform a visuospatial oddball task while undergoing an electroencephalogram. The UHR and first-episode groups showed reduced P300 amplitudes in comparison to healthy controls. P300 amplitudes were negatively correlated with severity of negative symptoms in both the UHR and first-episode groups. These results suggest that the visual P300 may be a neurobiological vulnerability marker, reflecting neurophysiological abnormalities associated with enduring negative symptoms in schizophrenia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394010012528
DOI
10.1016/j.neulet.2010.09.035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103076
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