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Reduced visual P300 amplitudes in individuals at ultra-high risk for psychosis and first-episode schizophrenia

DC Field Value Language
dc.contributor.author남궁기-
dc.contributor.author송동호-
dc.contributor.author안석균-
dc.date.accessioned2015-04-23T17:45:33Z-
dc.date.available2015-04-23T17:45:33Z-
dc.date.issued2010-
dc.identifier.issn0304-3940-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103076-
dc.description.abstractThe purpose of this study was to investigate whether individuals at ultra-high risk (UHR) for psychosis and patients experiencing first-episode schizophrenia had impairments in visual information processing as indexed by the visual P300 event-related potential. Sixteen UHR individuals, 21 first-episode schizophrenia patients, and 16 healthy controls were included. Participants were asked to perform a visuospatial oddball task while undergoing an electroencephalogram. The UHR and first-episode groups showed reduced P300 amplitudes in comparison to healthy controls. P300 amplitudes were negatively correlated with severity of negative symptoms in both the UHR and first-episode groups. These results suggest that the visual P300 may be a neurobiological vulnerability marker, reflecting neurophysiological abnormalities associated with enduring negative symptoms in schizophrenia.-
dc.description.statementOfResponsibilityopen-
dc.format.extent156~160-
dc.relation.isPartOfNEUROSCIENCE LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHBrain Mapping/methods-
dc.subject.MESHDisease Susceptibility-
dc.subject.MESHEarly Diagnosis-
dc.subject.MESHElectroencephalography/methods-
dc.subject.MESHEvent-Related Potentials,P300/physiology*-
dc.subject.MESHEvoked Potentials,Visual/physiology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHNeuropsychological Tests/standards-
dc.subject.MESHPhotic Stimulation/methods-
dc.subject.MESHPsychotic Disorders/diagnosis*-
dc.subject.MESHPsychotic Disorders/physiopathology*-
dc.subject.MESHRiskAssessment/methods-
dc.subject.MESHRiskFactors-
dc.subject.MESHSchizophrenia/diagnosis*-
dc.subject.MESHSchizophrenia/physiopathology*-
dc.subject.MESHVisualCortex/physiopathology*-
dc.subject.MESHVisualPathways/physiopathology-
dc.subject.MESHYoung Adult-
dc.titleReduced visual P300 amplitudes in individuals at ultra-high risk for psychosis and first-episode schizophrenia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorSu Young Lee-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorHye Hyun Cho-
dc.contributor.googleauthorDong-Ho Song-
dc.contributor.googleauthorSuk Kyoon An-
dc.identifier.doi10.1016/j.neulet.2010.09.035-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01240-
dc.contributor.localIdA02018-
dc.contributor.localIdA02227-
dc.relation.journalcodeJ02364-
dc.identifier.eissn1872-7972-
dc.identifier.pmid20858531-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304394010012528-
dc.subject.keywordUltra-high risk for psychosisFirst-episode schizophreniaP300Event-related potentialsNegative symptomsVisuospatial oddball task-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.alternativeNameSong, Dong Ho-
dc.contributor.alternativeNameAn, Suk Kyoon-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.contributor.affiliatedAuthorSong, Dong Ho-
dc.contributor.affiliatedAuthorAn, Suk Kyoon-
dc.citation.volume486-
dc.citation.number3-
dc.citation.startPage156-
dc.citation.endPage160-
dc.identifier.bibliographicCitationNEUROSCIENCE LETTERS, Vol.486(3) : 156-160, 2010-
dc.identifier.rimsid35668-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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